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HAMAP rule MF_00090

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General rule information [?]

Accession MF_00090
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name PIMT
Scope(s) Bacteria
Archaea
Template(s) Q56308 (PIMT_THEMA); Q8TZR3 (PIMT_PYRFU); [ Recover all ]
Triggered by HAMAP; MF_00090 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PIMT
Protein name RecName: Full=Protein-L-isoaspartate O-methyltransferase;
                 EC=2.1.1.77;
AltName: Full=L-isoaspartyl protein carboxyl methyltransferase;
AltName: Full=Protein L-isoaspartyl methyltransferase;
AltName: Full=Protein-beta-aspartate methyltransferase;
                 Short=PIMT;
Gene name Name=pcm;

Comments [?]

FUNCTIONCatalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
CATALYTIC ACTIVITY Reaction=[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:12705, Rhea:RHEA-COMP:12143, Rhea:RHEA- COMP:12144, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90596, ChEBI:CHEBI:90598; EC=2.1.1.77;
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family.

Keywords [?]

Cytoplasm
Transferase
Methyltransferase
S-adenosyl-L-methionine

Gene Ontology [?]

GO:0004719; Molecular function:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0036211; Biological process:protein modification process
GO:0030091; Biological process:protein repair
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01135; PCMT; 1;
NCBIfam TIGR00080; Pimt; 1;
PROSITE PS01279; PCMT; 1;

Features [?]

From: PIMT_ECOLI (P0A7A5)
Key From To Description Tag Condition FTGroup
ACT_SITE 59 59 S

Additional information [?]

Size range 198-327 amino acids
Related rules None
Fusion Nter: None Cter: <Unknown>
Comments Possible wrong starts. Unknown C-terminal domain in THEMA.



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