HAMAP

Accession	MF_00091
Dates	1-JUN-2001 (Created) 19-AUG-2011 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00091; [distribution of match scores in UniProtKB];[seed alignment for MF_00091]

Names

LuxS

Identifier

LUXS

Protein name

RecName: Full=S-ribosylhomocysteine lyase; EC=4.4.1.21; AltName: Full=AI-2 synthesis protein; AltName: Full=Autoinducer-2 production protein LuxS;

Gene name

luxS

FUNCTION: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity).

CATALYTIC ACTIVITY: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.

COFACTOR: Binds 1 iron ion per subunit (By similarity).

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the LuxS family.

Pfam	PF02664; LuxS; 1;
PRINTS	PR01487; LUXSPROTEIN; 1;

Quorum sensing, Autoinducer synthesis, Lyase.

Iron, Metal-binding.

GO:0043768; Molecular function: S-ribosylhomocysteine lyase activity.
GO:0009372; Biological process: quorum sensing.

From: LUXS_BACSU (O34667)
Key		From		To		Description		Condition		FTGroup
METAL		54		54		Iron (By similarity)		H		1
METAL		58		58		Iron (By similarity)		H		1
METAL		126		126		Iron (By similarity)		C		1

Size range:	151-173 amino acids
Related UniRules:	None
Template:	O34667 (LUXS_BACSU); Q9PN97 (LUXS_CAMJE); Q9RRU8 (LUXS_DEIRA); P45578 (LUXS_ECOLI); P44007 (LUXS_HAEIN): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None