HAMAP rule MF_00091

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00091
Accession	MF_00091
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 28)
Name	LuxS
Scope(s)	Bacteria
Template(s)	O34667 (LUXS_BACSU); Q9PN97 (LUXS_CAMJE); Q9RRU8 (LUXS_DEIRA); P45578 (LUXS_ECOLI); P44007 (LUXS_HAEIN); [ Recover all ]
Triggered by	HAMAP; MF_00091 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LUXS
Protein name	RecName: Full=S-ribosylhomocysteine lyase; EC=4.4.1.21; AltName: Full=AI-2 synthesis protein; AltName: Full=Autoinducer-2 production protein LuxS;
Gene name	Name=luxS;

Comments [?]

FUNCTION	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
CATALYTIC ACTIVITY	Reaction=S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5- dihydroxypentane-2,3-dione + L-homocysteine; Xref=Rhea:RHEA:17753, ChEBI:CHEBI:29484, ChEBI:CHEBI:58195, ChEBI:CHEBI:58199; EC=4.4.1.21;
case <FTGroup:1>
COFACTOR	Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
end case
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the LuxS family.

Keywords [?]

Gene Ontology [?]

GO:0043768; Molecular function:S-ribosylhomocysteine lyase activity

GO:0009372; Biological process:quorum sensing

Cross-references [?]

Pfam	PF02664; LuxS; 1;
PRINTS	PR01487; LUXSPROTEIN; 1;

Features [?]

From: LUXS_BACSU (O34667)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

126

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

Additional information [?]