HAMAP

Accession	MF_00093
Dates	1-JUN-2001 (Created) 28-OCT-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00093; [distribution of match scores in UniProtKB];[seed alignment for MF_00093]

Names

Rel_fac_1

Identifier

RF1

Protein name

RecName: Full=Peptide chain release factor 1; Short=RF-1;

Gene name

prfA

FUNCTION: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

PTM: Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).

SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor family.

Pfam	PF00472; RF-1; 1;
TIGRFAMs	TIGR00019; PrfA; 1;
PROSITE	PS00745; RF_PROK_I; 1;

Cytoplasm, Protein biosynthesis.

Methylation.

GO:0016149; Molecular function: translation release factor activity, codon specific.
GO:0006415; Biological process: translational termination.
GO:0005737; Cellular component: cytoplasm.

From: RF1_ECOLI (P0A7I0)
Key		From		To		Description		Condition		FTGroup
MOD_RES		235		235		N5-methylglutamine (By similarity)		Q

Size range:	342-375 amino acids
Related UniRules:	MF_00094 (RF2)
Template:	P0A7I0 (RF1_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None