HAMAP rule MF_00094
General rule information
[?]
| Accession | MF_00094 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 21) |
| Name | Rel_fac_2 |
| Scope(s) |
Bacteria |
| Template(s) | P07012 (RF2_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00094 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | RF2 |
| Protein name | RecName: Full=Peptide chain release factor 2; Short=RF-2; |
| Gene name | Name=prfB; |
Comments
[?]
| FUNCTION | Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| case <FT:1> | |
| PTM | Methylated by PrmC. Methylation increases the termination efficiency of RF2. |
| end case | |
| SIMILARITY | Belongs to the prokaryotic/mitochondrial release factor family. |
Keywords
[?]
| Cytoplasm | |
| Protein biosynthesis | |
| case <FT:1> | |
| Methylation | |
| end case | |
Gene Ontology
[?]
| GO:0016149; Molecular function:translation release factor activity, codon specific |
| GO:0006415; Biological process:translational termination |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Features
[?]
| From: RF2_ECOLI (P07012) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 252 | 252 | /note="N5-methylglutamine" | Q | ||||||||
Additional information
[?]
| Size range | 359-377 amino acids |
| Related rules |
MF_00093 |
| Fusion | Nter: None Cter: None |
| Comments | In about 70% of bacterial genomes the mRNA encoding RF-2 has 2 partially overlapping reading frames. Synthesis of full-length RF-2 requires +1 frameshifting at the end of the first open reading frame, usually on a UGA codon. This frameshifting serves an autoregulatory function; when RF-2 levels are low frameshifting occurs and full-length protein is produced. |