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HAMAP annotation rule: MF_00101
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General rule information

Accession MF_00101
Dates 1-JUN-2001 (Created)
16-MAY-2011 (Last updated, Version 30)
Data class Protein
Predictors HAMAP; MF_00101; [distribution of match scores in UniProtKB];[seed alignment for MF_00101]
Names AcpS


Propagated annotation

Identifier, protein and gene names
Identifier ACPS
Protein name
RecName: Full=Holo-[acyl-carrier-protein] synthase;
Short=Holo-ACP synthase;
EC=2.7.8.7;
AltName: Full=4'-phosphopantetheinyl transferase AcpS;
Gene name acpS
Comments
FUNCTION: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity).
CATALYTIC ACTIVITY: CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].

case <FT:1> or <FT:2>
COFACTOR: Magnesium (By similarity).
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the P-Pant transferase superfamily. AcpS family.
Cross-references
Pfam PF01648; ACPS; 1;
TIGRFAMs TIGR00516; AcpS; 1;
TIGR00556; Pantethn_trn; 1;
Keywords
Cytoplasm, Transferase, Lipid synthesis, Fatty acid biosynthesis.

case <FT:1> or <FT:2>
Magnesium, Metal-binding.
end case

Gene Ontology
GO:0008897; Molecular function: holo-[acyl-carrier-protein] synthase activity.

case <FT:1> or <FT:2>
GO:0000287; Molecular function: magnesium ion binding.
end case

GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: ACPS_ECOLI (P24224)
Key     From     To       Description   Condition   FTGroup
METAL     9     9       Magnesium (By similarity)   [DE]  
METAL     58     58       Magnesium (By similarity)   [EQ]  


Additional information

Size range: 108-157 amino acids
Related UniRules: None
Template: P96618 (ACPS_BACSU); P24224 (ACPS_ECOLI); P0A2W6 (ACPS_STRPN): [Recover all]
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: in ECO57
Plasmid encoded: None
Comments: Possible wrong C-terminal sequence in THEMA; not shown in alignment and not used in size range

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UniProtKB rule member sequences