HAMAP annotation rule MF_00104
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Accession MF_00104
Dates 1-JUN-2001 (Created)
21-FEB-2012 (Last updated, Version 25)
Name RNase_III
Scope Bacteria
Triggered by



Identifier
RNC
Protein name
RecName: Full=Ribonuclease 3;
EC=3.1.26.3;
AltName: Full=Ribonuclease III;
Short=RNase III;
Gene name
rnc


FUNCTION Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity).
CATALYTIC ACTIVITY Endonucleolytic cleavage to 5'-phosphomonoester.
COFACTOR Mg(2+) (By similarity).
SUBUNIT Homodimer (By similarity).
SUBCELLULAR LOCATION Cytoplasm (By similarity).


Cytoplasm
Hydrolase
Nuclease
Endonuclease
case <FT:3> or <FT:4> or <FT:5>
Magnesium
Metal-binding
end case
case <Feature:PS50137>
RNA-binding
rRNA-binding
end case
mRNA processing
rRNA processing
tRNA processing


GO:0004525; Molecular function: ribonuclease III activity.
GO:0006397; Biological process: mRNA processing.
GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.


Pfam PF00035; dsrm; 1;
PF00636; Ribonuclease_3; 1;
TIGRFAMs TIGR02191; RNaseIII; 1;
PROSITE PS50137; DS_RBD; 1; trigger=PRU00266;
PS00517; RNASE_3_1; 1;
PS50142; RNASE_3_2; 1; trigger=PRU00177;


From: RNC_AQUAE (O67082)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     44     44       Potential     D  
ACT_SITE     110     110       By similarity     E  
METAL     40     40       Magnesium (By similarity)     E  
METAL     107     107       Magnesium (By similarity)     [DENS]  
METAL     110     110       Magnesium (By similarity)     E  


Size range: 221-369 amino acids
Related Rules: None
Templates: O67082 (RNC_AQUAE); P51833 (RNC_BACSU); P0A7Y0 (RNC_ECOLI); Q52698 (RNC_RHOCA); Q56056 (RNC_SALTY); Q9ZBQ7 (RNC_STRCO); Q9X0I6 (RNC_THEMA): [Recover all]
Fusion: Nter: <Unknown>; Cter: None
Comments: Often predicted too short. Some Mycoplasmas lack the DRBM domain. Mycoplasma gallisepticum strains have an unknown N-terminal extension of about 400 aa. ROSHA and TRES6 are slightly longer in the middle; ROSHA has 2 DRBM domains.


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