HAMAP

Accession	MF_00105
Dates	1-JUN-2001 (Created) 30-MAY-2011 (Last updated, Version 16)

Data class

Protein

Predictors

HAMAP; MF_00105; [distribution of match scores in UniProtKB];[seed alignment for MF_00105]

Names

GreA_GreB

Identifier

GREA

Protein name

RecName: Full=Transcription elongation factor greA; AltName: Full=Transcript cleavage factor greA;

Gene name

greA

FUNCTION: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as greA or greB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity).

SIMILARITY: Belongs to the greA/greB family.

Pfam	PF01272; GreA_GreB; 1;
PROSITE	PS00829; GREAB_1; 1; PS00830; GREAB_2; 1;
General	Coiled_coil; -; 0-unlimited; trigger=Yes;

Transcription, Transcription regulation, DNA-binding.

GO:0003677; Molecular function: DNA binding.
GO:0032784; Biological process: regulation of transcription elongation, DNA-dependent.

Size range:	156-171 amino acids
Related UniRules:	None
Template:	P0A6W5 (GREA_ECOLI)
Scope:	Bacteria
Fusion:	Nter: <GRAD1>, <GRAD2>; Cter: None
Duplicate:	in ECO57, ECOLI, HAEIN, PASMU, PSEAE, SALTI, SALTY, VIBCH, XANAC, XANCP, YERPE
Plasmid encoded:	None
Comments:	In CHLPN and CHLTR the protein is fused to a N-terminal domain, GRAD1. In BORBU the protein is fused to both the GRAD1 domain and another N-terminal domain, GRAD2. Duplicate copy is called greB.