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HAMAP rule MF_00108
General rule information
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| Accession | MF_00108 |
| Dates | 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 34) |
| Name | IspD |
| Scope(s) |
Bacteria |
| Template(s) | Q46893 (ISPD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00108 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ISPD |
| Protein name | RecName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; EC=2.7.7.60; AltName: Full=4-diphosphocytidyl-2C-methyl-D-erythritol synthase; AltName: Full=MEP cytidylyltransferase; Short=MCT; |
| Gene name | Name=ispD; |
Comments
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| FUNCTION | Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). |
| CATALYTIC ACTIVITY | Reaction=2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C- methyl-D-erythritol + diphosphate; Xref=Rhea:RHEA:13429, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:57823, ChEBI:CHEBI:58262; EC=2.7.7.60; |
| PATHWAY | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5- phosphate: step 2/6. |
| case <OC:Enterobacterales> | |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. |
Keywords
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Gene Ontology
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| GO:0050518; Molecular function:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| GO:0019288; Biological process:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
Cross-references
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Features
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| From: ISPD_ECOLI (Q46893) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 20 | 20 | /note="Transition state stabilizer" | R | ||||||||
| SITE | 27 | 27 | /note="Transition state stabilizer" | K | ||||||||
| SITE | 157 | 157 | /note="Positions MEP for the nucleophilic attack" | R | ||||||||
| SITE | 213 | 213 | /note="Positions MEP for the nucleophilic attack" | K | ||||||||
Additional information
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| Size range | 211-291 amino acids |
| Related rules |
MF_01520 |
| Fusion | Nter: None Cter: None |
| Comments | See MF_01520 for bifunctional ispDF |