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HAMAP annotation rule: MF_00112
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General rule information

Accession MF_00112
Dates 1-JUN-2001 (Created)
9-DEC-2011 (Last updated, Version 19)
Data class Protein
Predictors HAMAP; MF_00112; [distribution of match scores in UniProtKB];[seed alignment for MF_00112]
Names GGGP_HepGP_synthase


Propagated annotation

Identifier, protein and gene names

case <OC:Archaea>
Identifier GGGPS
Protein name
RecName: Full=Geranylgeranylglyceryl phosphate synthase;
Short=GGGP synthase;
Short=GGGPS;
EC=2.5.1.41;
AltName: Full=(S)-3-O-geranylgeranylglyceryl phosphate synthase;
AltName: Full=Phosphoglycerol geranylgeranyltransferase;
end case


case <OC:Bacillales>
Identifier PCRB
Protein name
RecName: Full=Heptaprenylglyceryl phosphate synthase;
Short=HepGP synthase;
EC=2.5.1.n9;
AltName: Full=Glycerol-1-phosphate heptaprenyltransferase;
Gene name pcrB
end case

Comments

case <OC:Archaea>
FUNCTION: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids (By similarity).
CATALYTIC ACTIVITY: Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.
COFACTOR: Magnesium (By similarity).
PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
end case


case <OC:Bacillales>
FUNCTION: Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity).
CATALYTIC ACTIVITY: All-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(all-trans-heptaprenyl)glycerol 1-phosphate.
COFACTOR: Magnesium (By similarity).
PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism.
SUBUNIT: Homodimer (By similarity).
end case

SIMILARITY: Belongs to the GGGP/HepGP synthase family.
Cross-references
Pfam PF01884; PcrB; 1;
TIGRFAMs TIGR01768; GGGP-family; 1;
TIGR01769; GGGP; 1;
Keywords

case <OC:Archaea>
Cytoplasm.
end case

Magnesium, Metal-binding, Phospholipid biosynthesis, Transferase.
Gene Ontology

case <OC:Archaea>
GO:0047294; Molecular function: phosphoglycerol geranylgeranyltransferase activity.
GO:0005737; Cellular component: cytoplasm.
end case


case <OC:Bacillales>
GO:0002094; Molecular function: polyprenyltransferase activity.
end case

GO:0000287; Molecular function: magnesium ion binding.
GO:0046474; Biological process: glycerophospholipid biosynthetic process.
Features
From: GGGPS_ARCFU (O29844)
Key     From     To       Description   Condition   FTGroup
REGION     165     167       Glycerol-1-phosphate binding (By similarity)   Y-x-E  
METAL     13     13       Magnesium (Potential)   D  
METAL     39     39       Magnesium (Potential)   [ST]  
BINDING (Optional)     11     11       Glycerol-1-phosphate (By similarity)   K  
BINDING (Optional)     170     170       Glycerol-1-phosphate; via amide nitrogen (By similarity)   G  
BINDING     195     195       Glycerol-1-phosphate; via amide nitrogen (By similarity)   G  
BINDING (Optional)     216     216       Glycerol-1-phosphate (By similarity)   [ND]  


Additional information

Size range: 225-267 amino acids
Related UniRules: None
Template: O29844 (GGGPS_ARCFU); P0C882 (GGGPS_METTM); Q9HJH3 (GGGPS_THEAC); B0R2Z3 (GGGPS_HALS3); Q980N1 (GGGPS_SULSO); O26652 (GGGPS_METTH); Q5JDY1 (GGGPS_PYRKO); O34790 (PCRB_BACSU); Q53726 (PCRB_STAA8); Q8Y6C8 (PCRB_LISMO); Q81ZG3 (PCRB_BACAN); Q5L3C1 (PCRB_GEOKA): [Recover all]
Scope: Bacteria; Bacillales
Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences