HAMAP rule MF_00115

General rule information [?]

Accession	MF_00115
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 48)
Name	MscL
Scope(s)	Bacteria
Template(s)	P0A742 (MSCL_ECOLI); P9WJN5 (MSCL_MYCTU); P68806 (MSCL_STAAW); P94585 (MSCL_BACSU); O68284 (MSCL_PECCA); P44789 (MSCL_HAEIN); P68805 (MSCL_STAA8); [ Recover all ]
Triggered by	HAMAP; MF_00115 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MSCL
Protein name	RecName: Full=Large-conductance mechanosensitive channel;
Gene name	Name=mscL;

Comments [?]

FUNCTION	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
SUBUNIT	Homopentamer.
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
else
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the MscL family.

Keywords [?]

case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
Cell inner membrane
end case
Cell membrane
Ion channel
Ion transport
Membrane
Transmembrane
Transport
Transmembrane helix

Gene Ontology [?]

GO:0008381; Molecular function:mechanosensitive monoatomic ion channel activity

GO:0034220; Biological process:monoatomic ion transmembrane transport

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]