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| HAMAP annotation rule MF_00116 |
| Accession |
MF_00116 |
| Dates |
1-JUN-2001 (Created)
16-MAY-2011 (Last updated, Version 23) |
| Protein name |
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RecName:
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Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
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Short=dUTPase;
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EC=3.6.1.23;
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AltName:
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Full=dUTP pyrophosphatase;
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| FUNCTION |
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity). |
| CATALYTIC ACTIVITY |
dUTP + H(2)O = dUMP + diphosphate. |
| COFACTOR |
Magnesium (By similarity). |
| PATHWAY |
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route); step 2/2. |
case <OC:Escherichia> or <OC:Mycobacterium>
| SUBUNIT |
Homotrimer (By similarity). |
end case
| SIMILARITY |
Belongs to the dUTPase family. |
GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
| From: DUT_ECOLI (P06968) |
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Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION (Optional)
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70
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72
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Substrate binding (By similarity)
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R-S-[GS]
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REGION (Optional)
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87
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89
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Substrate binding (By similarity)
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[TVL]-[IV]-D
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BINDING (Optional)
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83
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83
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Substrate (By similarity)
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[NQ]
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case not <FT:2>
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BINDING (Optional)
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89
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89
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Substrate (By similarity)
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D
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end case
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BINDING (Optional)
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97
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97
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Substrate; via amide nitrogen and carbonyl oxygen (By similarity)
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[KM]
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| Size range: |
139-185 amino acids |
| Related Rules: |
None |
| Templates: |
P06968 (DUT_ECOLI); P0A552 (DUT_MYCTU): [Recover all] |
| Fusion: |
None |