HAMAP

Accession	MF_00124
Dates	1-JUN-2001 (Created) 19-OCT-2010 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00124; [distribution of match scores in UniProtKB];[seed alignment for MF_00124]

Names

Thymidine_kinase

Identifier

KITH

Protein name

RecName: Full=Thymidine kinase; EC=2.7.1.21;

Gene name

tdk

CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-phosphate.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the thymidine kinase family.

Pfam	PF00265; TK; 1;
PROSITE	PS00603; TK_CELLULAR_TYPE; 1;

Cytoplasm, Transferase, Kinase, DNA synthesis, ATP-binding, Nucleotide-binding.

Metal-binding, Zinc.

GO:0005524; Molecular function: ATP binding.
GO:0004797; Molecular function: thymidine kinase activity.

GO:0008270; Molecular function: zinc ion binding.

GO:0006259; Biological process: DNA metabolic process.
GO:0005737; Cellular component: cytoplasm.

From: KITH_CLOAB (Q97F65)
Key		From		To		Description		Condition		FTGroup
NP_BIND		15		22		ATP (By similarity)		[GSA]-x(4)-G-K-[ST]
NP_BIND		88		91		ATP (By similarity)		[DE]-E-x-[QHN]
ACT_SITE		89		89		Proton acceptor (Potential)		E
METAL (Optional)		145		145		Zinc (By similarity)		C		1
METAL (Optional)		148		148		Zinc (By similarity)		C		1
METAL (Optional)		183		183		Zinc (By similarity)		C		1
METAL (Optional)		186		186		Zinc (By similarity)		[CH]		1

Size range:	184-227 amino acids
Related UniRules:	None
Template:	Q97F65 (KITH_CLOAB); Q9PPP5 (KITH_UREPA); P23331 (KITH_ECOLI); Q81JX0 (KITH_BACAN); Q814U0 (KITH_BACCR); Q9WYN2 (KITH_THEMA): [Recover all]
Scope:	Archaea Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	There is a divergent tdk in a Bacillus natto plasmid (O52951)