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HAMAP rule MF_00132

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General rule information [?]

Accession MF_00132
Dates 1-JUN-2001 (Created)
17-OCT-2023 (Last updated, Version 37)
Name Top6A
Scope(s) Archaea
Bacteria
Template(s) Q57815 (TOP6A_METJA); Q8PUB7 (TOP6A_METMA); O05208 (TOP6A_SACSH); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_00132 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TOP6A
Protein name RecName: Full=Type 2 DNA topoisomerase 6 subunit A;
                 EC=5.6.2.2;
AltName: Full=Type II DNA topoisomerase VI subunit A;
Gene name Name=top6A;

Comments [?]

FUNCTIONRelaxes both positive and negative superturns and exhibits a strong decatenase activity.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SUBUNITHomodimer. Heterotetramer of two Top6A and two Top6B chains.
SIMILARITYBelongs to the TOP6A family.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0000287; Molecular function:magnesium ion binding
GO:0006265; Biological process:DNA topological change
GO:0006268; Biological process:DNA unwinding involved in DNA replication

Cross-references [?]

Pfam PF04406; TP6A_N; 1;
PRINTS PR01550; TOP6AFAMILY; 1;
PRINTS PR01552; TPISMRASE6A; 1;
PROSITE PS52041; TOPO_IIB; 1;

Features [?]

From: TOP6A_METJA (Q57815)
Key From To Description Tag Condition FTGroup
ACT_SITE 103 103 /note="O-(5'-phospho-DNA)-tyrosine intermediate" Y
BINDING 197 197 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E
BINDING 249 249 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D

Additional information [?]

Size range 340-453 amino acids
Related rules None
Fusion Nter: None Cter: None



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