HAMAP rule MF_00132
General rule information
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| Accession | MF_00132 |
| Dates | 1-JUN-2001 (Created)
17-OCT-2023 (Last updated, Version 37) |
| Name | Top6A |
| Scope(s) |
Archaea Bacteria |
| Template(s) | Q57815 (TOP6A_METJA); Q8PUB7 (TOP6A_METMA); O05208 (TOP6A_SACSH); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_00132 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TOP6A |
| Protein name | RecName: Full=Type 2 DNA topoisomerase 6 subunit A; EC=5.6.2.2; AltName: Full=Type II DNA topoisomerase VI subunit A; |
| Gene name | Name=top6A; |
Comments
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| FUNCTION | Relaxes both positive and negative superturns and exhibits a strong decatenase activity. |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Homodimer. Heterotetramer of two Top6A and two Top6B chains. |
| SIMILARITY | Belongs to the TOP6A family. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0006265; Biological process:DNA topological change |
| GO:0006268; Biological process:DNA unwinding involved in DNA replication |
Cross-references
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| Pfam | PF04406; TP6A_N; 1; |
| PRINTS | PR01550; TOP6AFAMILY; 1; |
| PRINTS | PR01552; TPISMRASE6A; 1; |
| PROSITE | PS52041; TOPO_IIB; 1; |
Features
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| From: TOP6A_METJA (Q57815) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 103 | 103 | /note="O-(5'-phospho-DNA)-tyrosine intermediate" | Y | ||||||||
| BINDING | 197 | 197 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 249 | 249 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
Additional information
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| Size range | 340-453 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |