HAMAP

Accession	MF_00132
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00132; [distribution of match scores in UniProtKB];[seed alignment for MF_00132]

Names

Top6A

Identifier

TOP6A

Protein name

RecName: Full=Type 2 DNA topoisomerase 6 subunit A; EC=5.99.1.3; AltName: Full=Type II DNA topoisomerase VI subunit A;

Gene name

top6A

FUNCTION: Relaxes both positive and negative superturns and exhibits a strong decatenase activity (By similarity).

CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining of double-stranded DNA.

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

SUBUNIT: Heterotetramer of two subunits A and two subunits B (By similarity).

SIMILARITY: Belongs to the TOP6A family.

Pfam	PF04406; TP6A_N; 1;

ATP-binding, DNA-binding, Isomerase, Magnesium, Metal-binding, Nucleotide-binding, Topoisomerase.

GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase (ATP-hydrolyzing) activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in replication.

From: TOP6A_METJA (Q57815)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		103		103		For DNA cleavage activity (By similarity)		Y
METAL		197		197		Magnesium (By similarity)		E
METAL		249		249		Magnesium (By similarity)		D

Size range:	353-389 amino acids
Related UniRules:	None
Template:	Q57815 (TOP6A_METJA)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None