HAMAP

Accession	MF_00133
Dates	1-JUN-2001 (Created) 18-AUG-2011 (Last updated, Version 38)

Data class

Protein

Predictors

HAMAP; MF_00133; [distribution of match scores in UniProtKB];[seed alignment for MF_00133]

Names

Trp_synth_beta

Identifier

TRPB

Protein name

RecName: Full=Tryptophan synthase beta chain; EC=4.2.1.20;

Gene name

trpB

FUNCTION: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine (By similarity).

CATALYTIC ACTIVITY: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O.

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.

SUBUNIT: Tetramer of two alpha and two beta chains (By similarity).

SIMILARITY: Belongs to the TrpB family.

Pfam	PF00291; PALP; 1;
TIGRFAMs	TIGR00263; TrpB; 1;
PROSITE	PS00168; TRP_SYNTHASE_BETA; 1;

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis, Pyridoxal phosphate, Lyase.

GO:0004834; Molecular function: tryptophan synthase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.

From: TRPB_ECOLI (P0A879)
Key		From		To		Description		Condition		FTGroup
MOD_RES		87		87		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	388-459 amino acids
Related UniRules:	None
Template:	P0A2K1 (TRPB_SALTY); P0A879 (TRPB_ECOLI); Q8U093 (TRPB1_PYRFU): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in AERPE, NOSS1, AQUAE, ARCFU, COREF, VIBPA, WOLSU, METTH, PYRAB, PYRFU, THEMA
Plasmid encoded:	None
Comments:	Highly divergent CHLTR; sequence not included in alignment. Duplicated trpB seems of archaebacterial origin. Some archaea have only such form (AERPE), some have only the classical form (METJA) and some have both including two bacteria (AQUAE and THEMA).