HAMAP

Accession	MF_00136
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00136; [distribution of match scores in UniProtKB];[seed alignment for MF_00136]

Names

S-AdoMet_synth2

Identifier

METK

Protein name

RecName: Full=S-adenosylmethionine synthase; Short=AdoMet synthase; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase;

Identifier

METL

Protein name

RecName: Full=Probable S-adenosylmethionine synthase; Short=AdoMet synthase; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase;

Gene name

mat

FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity).

CATALYTIC ACTIVITY: ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.

COFACTOR: Magnesium (By similarity).

PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

SIMILARITY: Belongs to the AdoMet synthase 2 family.

Pfam	PF01941; AdoMet_Synthase; 1;

Transferase, One-carbon metabolism, ATP-binding, Nucleotide-binding, Magnesium.

GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004478; Molecular function: methionine adenosyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.

From: METK_METJA (Q58605)
Key		From		To		Description		Condition		FTGroup
NP_BIND		141		146		ATP (Potential)		[GK]-x-G-S-x-D

Size range:	397-410 amino acids
Related UniRules:	None
Template:	Q58605 (METK_METJA)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	AQUAE seems to have 2 copies of S-adenosylmethionine synthase, one (O67222) belonging to the S-adenosylmethionine synthase type 1 family (MF_00086) and the other (O67275) matching the type 2 family (this HAMAP rule).