HAMAP rule MF_00136
General rule information
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Accession | MF_00136 |
Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 32) |
Name | S_AdoMet_synth2 |
Scope(s) |
Bacteria Archaea |
Template(s) | Q58605 (METK_METJA); [ Recover all ] |
Triggered by |
HAMAP; MF_00136 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Archaea> | |
Identifier | METK |
Protein name | RecName: Full=S-adenosylmethionine synthase; Short=AdoMet synthase; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase; |
end case | |
case <OC:Bacteria> | |
Identifier | METL |
Protein name | RecName: Full=Probable S-adenosylmethionine synthase; Short=AdoMet synthase; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase; |
end case | |
Gene name | Name=mat; |
Comments
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FUNCTION | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. |
CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-methionine = diphosphate + phosphate + S- adenosyl-L-methionine; Xref=Rhea:RHEA:21080, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789; EC=2.5.1.6; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
PATHWAY | Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. |
SIMILARITY | Belongs to the AdoMet synthase 2 family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0000287; Molecular function:magnesium ion binding |
GO:0004478; Molecular function:methionine adenosyltransferase activity |
GO:0006730; Biological process:one-carbon metabolic process |
Cross-references
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Pfam | PF01941; AdoMet_Synthase; 1; |
Features
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From: METK_METJA (Q58605) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 141 | 146 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GK]-x-G-S-x-D |
Additional information
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Size range | 397-410 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | AQUAE seems to have 2 copies of S-adenosylmethionine synthase, one (O67222) belonging to the S-adenosylmethionine synthase type 1 family (MF_00086) and the other (O67275) matching the type 2 family (this HAMAP rule). |