HAMAP

Accession	MF_00137
Dates	1-JUN-2001 (Created) 16-MAY-2011 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00137; [distribution of match scores in UniProtKB];[seed alignment for MF_00137]

Names

SAICAR_synth

Identifier

PUR7

Protein name

RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase; EC=6.3.2.6; AltName: Full=SAICAR synthetase;

Gene name

purC

CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.

PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.

SIMILARITY: Belongs to the SAICAR synthetase family.

Pfam	PF01259; SAICAR_synt; 1;
TIGRFAMs	TIGR00081; PurC; 1;
PROSITE	PS01057; SAICAR_SYNTHETASE_1; 1; PS01058; SAICAR_SYNTHETASE_2; 1;

ATP-binding, Ligase, Nucleotide-binding, Purine biosynthesis.

GO:0004639; Molecular function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.

Size range:	216-367 amino acids
Related UniRules:	None
Template:	P0A7D7 (PUR7_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in AGRT5, BRAJA, CAUCR, RHILO
Plasmid encoded:	None
Comments:	Highly divergent ARCFU and HALSA; sequences not included in alignment. Seems to be absent in AERPE. Some of the Alphaproteobacteria have a possible second copy.