HAMAP annotation rule: MF_00137
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Accession MF_00137
Dates 1-JUN-2001 (Created)
16-MAY-2011 (Last updated, Version 31)
Data class Protein
Names SAICAR_synth



Identifier PUR7
Protein name
RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
EC=6.3.2.6;
AltName: Full=SAICAR synthetase;
Gene name purC
CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
SIMILARITY: Belongs to the SAICAR synthetase family.
Pfam PF01259; SAICAR_synt; 1;
TIGRFAMs TIGR00081; PurC; 1;
PROSITE PS01057; SAICAR_SYNTHETASE_1; 1;
PS01058; SAICAR_SYNTHETASE_2; 1;
GO:0004639; Molecular function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.



Size range: 216-367 amino acids
Related UniRules: None
Template: P0A7D7 (PUR7_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in AGRT5, BRAJA, CAUCR, RHILO
Plasmid encoded: None
Comments: Highly divergent ARCFU and HALSA; sequences not included in alignment. Seems to be absent in AERPE. Some of the Alphaproteobacteria have a possible second copy.

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