HAMAP annotation rule MF_00137
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Accession MF_00137
Dates 1-JUN-2001 (Created)
16-MAY-2011 (Last updated, Version 31)
Name SAICAR_synth
Scope Bacteria
Archaea
Triggered by



Identifier
PUR7
Protein name
RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
EC=6.3.2.6;
AltName: Full=SAICAR synthetase;
Gene name
purC


CATALYTIC ACTIVITY ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate; step 1/2.
SIMILARITY Belongs to the SAICAR synthetase family.


ATP-binding
Ligase
Nucleotide-binding
Purine biosynthesis


GO:0004639; Molecular function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.


Pfam PF01259; SAICAR_synt; 1;
TIGRFAMs TIGR00081; PurC; 1;
PROSITE PS01057; SAICAR_SYNTHETASE_1; 1;
PS01058; SAICAR_SYNTHETASE_2; 1;


Size range: 216-367 amino acids
Related Rules: None
Template: P0A7D7 (PUR7_ECOLI)
Fusion: None
Comments: Highly divergent ARCFU and HALSA; sequences not included in alignment. Seems to be absent in AERPE. Some of the Alphaproteobacteria have a possible second copy.


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