HAMAP rule MF_00137
General rule information
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Accession | MF_00137 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39) |
Name | SAICAR_synth |
Scope(s) |
Bacteria Archaea |
Template(s) | P0A7D7 (PUR7_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00137 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PUR7 |
Protein name | RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase; EC=6.3.2.6; AltName: Full=SAICAR synthetase; |
Gene name | Name=purC; |
Comments
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CATALYTIC ACTIVITY | Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole- 4-carboxamido]succinate + ADP + 2 H(+) + phosphate; Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443, ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6; |
PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. |
SIMILARITY | Belongs to the SAICAR synthetase family. |
Keywords
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Gene Ontology
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GO:0004639; Molecular function:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
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Pfam | PF01259; SAICAR_synt; 1; |
NCBIfam | TIGR00081; purC; 1; |
NCBIfam | TIGR02735; purC_vibrio; 0-1; |
PROSITE | PS01057; SAICAR_SYNTHETASE_1; 1; |
PROSITE | PS01058; SAICAR_SYNTHETASE_2; 1; |
Features
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Additional information
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Size range | 216-367 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Highly divergent ARCFU and HALSA; sequences not included in alignment. Seems to be absent in AERPE. Some of the Alphaproteobacteria have a possible second copy. |