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HAMAP rule MF_00138

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General rule information [?]

Accession MF_00138
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name GARS
Scope(s) Bacteria
Archaea
Template(s) P15640 (PUR2_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00138 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PUR2
Protein name RecName: Full=Phosphoribosylamine--glycine ligase;
                 EC=6.3.4.13;
AltName: Full=GARS;
AltName: Full=Glycinamide ribonucleotide synthetase;
AltName: Full=Phosphoribosylglycinamide synthetase;
Gene name Name=purD;

Comments [?]

CATALYTIC ACTIVITY Reaction=5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate; Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58681, ChEBI:CHEBI:143788, ChEBI:CHEBI:456216; EC=6.3.4.13;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; N(1)- (5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1- diphosphate: step 2/2.
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
SUBUNITMonomer.
end case
SIMILARITYBelongs to the GARS family.

Keywords [?]


Gene Ontology [?]

GO:0004637; Molecular function:phosphoribosylamine-glycine ligase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Pfam PF01071; GARS_A; 1;
Pfam PF02843; GARS_C; 1;
Pfam PF02844; GARS_N; 1;
NCBIfam TIGR00877; PurD; 1;
PROSITE PS00184; GARS; 1;
PROSITE PS50975; ATP_GRASP; 1;

Features [?]


Additional information [?]

Size range 400-444 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments ARCFU is divergent, it has an insertion not found in other purD



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