HAMAP

Accession	MF_00138
Dates	1-JUN-2001 (Created) 16-MAY-2011 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00138; [distribution of match scores in UniProtKB];[seed alignment for MF_00138]

Names

GARS

Identifier

PUR2

Protein name

RecName: Full=Phosphoribosylamine--glycine ligase; EC=6.3.4.13; AltName: Full=GARS; AltName: Full=Glycinamide ribonucleotide synthetase; AltName: Full=Phosphoribosylglycinamide synthetase;

Gene name

purD

CATALYTIC ACTIVITY: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.

PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.

SUBUNIT: Monomer (By similarity).

SIMILARITY: Belongs to the GARS family.

Pfam	PF01071; GARS_A; 1; PF02843; GARS_C; 1; PF02844; GARS_N; 1;
TIGRFAMs	TIGR00877; PurD; 1;
PROSITE	PS00184; GARS; 1; PS50975; ATP_GRASP; 1; trigger=PRU00409;

Purine biosynthesis, Ligase.

GO:0004637; Molecular function: phosphoribosylamine-glycine ligase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.

Size range:	400-444 amino acids
Related UniRules:	None
Template:	P15640 (PUR2_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	ARCFU is divergent, it has an insertion not found in other purD