HAMAP logo

HAMAP rule MF_00139

Send feedback

General rule information [?]

Accession MF_00139
Dates 1-JUN-2001 (Created)
18-JUL-2023 (Last updated, Version 34)
Name PurH
Scope(s) Bacteria
Template(s) P31335 (PUR9_CHICK); P31939 (PUR9_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_00139 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PUR9
RecName: Full=Bifunctional purine biosynthesis protein PurH;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Includes:<br /> RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/2.1.2.3">2.1.2.3</a>;<br /> AltName: Full=AICAR transformylase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Includes:<br /> RecName: Full=IMP cyclohydrolase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.5.4.10">3.5.4.10</a>;<br /> AltName: Full=ATIC;<br /> AltName: Full=IMP synthase;<br /> AltName: Full=Inosinicase;
Gene name Name=purH;

Comments [?]

CATALYTIC ACTIVITY Reaction=(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:22192, ChEBI:CHEBI:57453, ChEBI:CHEBI:58467, ChEBI:CHEBI:58475, ChEBI:CHEBI:195366; EC=2.1.2.3;
CATALYTIC ACTIVITY Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377, ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
DOMAINThe IMP cyclohydrolase activity resides in the N-terminal region.
SIMILARITYBelongs to the PurH family.

Keywords [?]

case (<OC:Escherichia> or <OC:Shigella>) and <FT:1>
Acetylation
end case
Hydrolase
Multifunctional enzyme
Purine biosynthesis
Transferase

Gene Ontology [?]

GO:0003937; Molecular function:IMP cyclohydrolase activity
GO:0004643; Molecular function:phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Pfam PF01808; AICARFT_IMPCHas; 1;
Pfam PF02142; MGS; 1;
NCBIfam TIGR00355; PurH; 1;
PROSITE PS51855; MGS; 1;

Features [?]

From: PUR9_ECOLI (P15639)
Key From To Description Tag Condition FTGroup
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 287 287 /note="N6-acetyllysine" K
end case

Additional information [?]

Size range 492-545 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Divergent THEMA; sequence not included in alignment and not taken into account in size range



View rule in raw text format (no links)