HAMAP rule MF_00139
General rule information
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| Accession | MF_00139 |
| Dates | 1-JUN-2001 (Created)
18-JUL-2023 (Last updated, Version 34) |
| Name | PurH |
| Scope(s) |
Bacteria |
| Template(s) | P31335 (PUR9_CHICK); P31939 (PUR9_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_00139 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PUR9 |
| RecName: Full=Bifunctional purine biosynthesis protein PurH;<br /> Includes:<br /> RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;<br /> EC=<a href="https://enzyme.expasy.org/EC/2.1.2.3">2.1.2.3</a>;<br /> AltName: Full=AICAR transformylase;<br /> Includes:<br /> RecName: Full=IMP cyclohydrolase;<br /> EC=<a href="https://enzyme.expasy.org/EC/3.5.4.10">3.5.4.10</a>;<br /> AltName: Full=ATIC;<br /> AltName: Full=IMP synthase;<br /> AltName: Full=Inosinicase; | |
| Gene name | Name=purH; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:22192, ChEBI:CHEBI:57453, ChEBI:CHEBI:58467, ChEBI:CHEBI:58475, ChEBI:CHEBI:195366; EC=2.1.2.3; |
| CATALYTIC ACTIVITY | Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377, ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10; |
| PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. |
| PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. |
| DOMAIN | The IMP cyclohydrolase activity resides in the N-terminal region. |
| SIMILARITY | Belongs to the PurH family. |
Keywords
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| case (<OC:Escherichia> or <OC:Shigella>) and <FT:1> | |
| Acetylation | |
| end case | |
| Hydrolase | |
| Multifunctional enzyme | |
| Purine biosynthesis | |
| Transferase | |
Gene Ontology
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| GO:0003937; Molecular function:IMP cyclohydrolase activity |
| GO:0004643; Molecular function:phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
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| Pfam | PF01808; AICARFT_IMPCHas; 1; |
| Pfam | PF02142; MGS; 1; |
| NCBIfam | TIGR00355; PurH; 1; |
| PROSITE | PS51855; MGS; 1; |
Features
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| From: PUR9_ECOLI (P15639) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 287 | 287 | /note="N6-acetyllysine" | K | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 492-545 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Divergent THEMA; sequence not included in alignment and not taken into account in size range |