HAMAP

Accession	MF_00139
Dates	1-JUN-2001 (Created) 12-AUG-2011 (Last updated, Version 27)

Data class

Protein

Predictors

HAMAP; MF_00139; [distribution of match scores in UniProtKB];[seed alignment for MF_00139]

Names

PurH

Identifier

PUR9

Protein name

RecName: Full=Bifunctional purine biosynthesis protein PurH; RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase; EC=2.1.2.3; AltName: Full=AICAR transformylase; RecName: Full=IMP cyclohydrolase; EC=3.5.4.10; AltName: Full=ATIC; AltName: Full=IMP synthase; AltName: Full=Inosinicase;

Gene name

purH

CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.

PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal region (By similarity).

SIMILARITY: Belongs to the PurH family.

Pfam	PF01808; AICARFT_IMPCHas; 1; PF02142; MGS; 1;
TIGRFAMs	TIGR00355; PurH; 1;

Acetylation.

Hydrolase, Multifunctional enzyme, Purine biosynthesis, Transferase.

GO:0003937; Molecular function: IMP cyclohydrolase activity.
GO:0004643; Molecular function: phosphoribosylaminoimidazolecarboxamide formyltransferase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.

From: PUR9_ECOLI (P15639)
Key		From		To		Description		Condition		FTGroup
MOD_RES		287		287		N6-acetyllysine (By similarity)		K

Size range:	492-545 amino acids
Related UniRules:	None
Template:	P31335 (PUR9_CHICK); P31939 (PUR9_HUMAN): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Divergent THEMA; sequence not included in alignment and not taken into account in size range