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HAMAP annotation rule: MF_00145
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General rule information

Accession MF_00145
Dates 1-JUN-2001 (Created)
9-DEC-2011 (Last updated, Version 30)
Data class Protein
Predictors HAMAP; MF_00145; [distribution of match scores in UniProtKB];[seed alignment for MF_00145]
Names Phosphoglyc_kinase


Propagated annotation

Identifier, protein and gene names
Identifier PGK
Protein name
RecName: Full=Phosphoglycerate kinase;
EC=2.7.2.3;
Gene name pgk
Comments
CATALYTIC ACTIVITY: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the phosphoglycerate kinase family.
Cross-references
Pfam PF00162; PGK; 1;
PRINTS PR00477; PHGLYCKINASE; 1;
PROSITE PS00111; PGLYCERATE_KINASE; 1;
Keywords

case <FT:10>
Acetylation.
end case

Cytoplasm, ATP-binding, Glycolysis, Kinase, Nucleotide-binding, Transferase.

case <FT:11> or <FT:12>
Phosphoprotein.
end case

Gene Ontology
GO:0004618; Molecular function: phosphoglycerate kinase activity.
GO:0006096; Biological process: glycolysis.
GO:0005737; Cellular component: cytoplasm.
Features
From: PGKT_THEMA (P36204)
Key     From     To       Description   Condition   FTGroup
NP_BIND     353     356       ATP (By similarity)   G-G-[DEH]-[STAILFM]  
REGION     21     23       Substrate binding (By similarity)   D-[LFMYVI]-N  
REGION     59     62       Substrate binding (By similarity)   [HQR]-x-[GSDRK]-[RGKNDP]  
BINDING (Optional)     36     36       Substrate (By similarity)   R  
BINDING (Optional)     118     118       Substrate (By similarity)   R  
BINDING (Optional)     151     151       Substrate (By similarity)   R  
BINDING (Optional)     201     201       ATP (By similarity)   K  
BINDING (Optional)     293     293       ATP; via carbonyl oxygen (By similarity)   G  
BINDING (Optional)     324     324       ATP (By similarity)   E  
case <OC:Escherichia> or <OC:Shigella>
From: PGK_ECOLI (P0A799)
Key     From     To       Description   Condition   FTGroup
MOD_RES     84     84       N6-acetyllysine (By similarity)   K  
end case

case <OC:Bacillaceae>
From: PGK_BACSU (P40924)
Key     From     To       Description   Condition   FTGroup
MOD_RES     183     183       Phosphoserine (By similarity)   S  
MOD_RES     299     299       Phosphothreonine (By similarity)   T  
end case



Additional information

Size range: 385-419 amino acids
Related UniRules: None
Template: P18912 (PGK_GEOSE); Q8GIZ5 (PGK_LACDL); P36204 (PGKT_THEMA); P09403 (PGK_THET8); P61884 (PGK_PYRWO): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: MF_00147 (tpiA), <Unknown>
Duplicate: in CUPNH, METAC
Plasmid encoded: in CUPNH

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UniProtKB rule member sequences