HAMAP rule MF_00147
General rule information
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| Accession | MF_00147 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 45) |
| Name | TIM |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P9WG43 (TPIS_MYCTU); P00943 (TPIS_GEOSE); P0A858 (TPIS_ECOLI); Q6GIL6 (TPIS_STAAR); P50921 (TPIS_MORMI); P56076 (TPIS_HELPY); P62003 (TPIS_PYRWO); Q58923 (TPIS_METJA); O74025 (TPIS_METBR); Q8NKN9 (TPIS_THETK); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_00147_B (Get profile general information and statistics) end case
case c? <OC:Archaea>
HAMAP; MF_00147_A (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TPIS |
| Protein name | RecName: Full=Triosephosphate isomerase; Short=TIM; Short=TPI; EC=5.3.1.1; AltName: Full=Triose-phosphate isomerase; |
| Gene name | Name=tpiA; |
Comments
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| FUNCTION | Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). |
| CATALYTIC ACTIVITY | Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate; Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=5.3.1.1; |
| PATHWAY | Carbohydrate biosynthesis; gluconeogenesis. |
| PATHWAY | Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate from glycerone phosphate: step 1/1. |
| case <OC:Archaea> | |
| SUBUNIT | Homotetramer; dimer of dimers. |
| end case | |
| case not <OC:Archaea> | |
| SUBUNIT | Homodimer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the triosephosphate isomerase family. |
Keywords
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| Cytoplasm | |
| Isomerase | |
| Glycolysis | |
| Gluconeogenesis | |
| case <FT:7> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0004807; Molecular function:triose-phosphate isomerase activity |
| GO:0006094; Biological process:gluconeogenesis |
| GO:0006096; Biological process:glycolytic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: TPIS_MYCTU (P9WG43) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| BINDING | 10 | 12 | /ligand="substrate" | N-x-K | ||||||||
| BINDING | 239 | 240 | /ligand="substrate" | G-G | ||||||||
| ACT_SITE | 100 | 100 | /note="Electrophile" | H | ||||||||
| ACT_SITE | 172 | 172 | /note="Proton acceptor" | E | ||||||||
| BINDING | 178 | 178 | /ligand="substrate" | G | ||||||||
| BINDING | 218 | 218 | /ligand="substrate" | S | ||||||||
| end case | ||||||||||||
| From: TPIS_BACSU (P27876) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacillaceae> | ||||||||||||
| MOD_RES | 213 | 213 | /note="Phosphoserine" | S | ||||||||
| end case | ||||||||||||
| From: TPIS_PYRWO (P62003) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Archaea> | ||||||||||||
| BINDING | 12 | 14 | /ligand="substrate" | N-x-K | ||||||||
| BINDING | 205 | 206 | /ligand="substrate" | A-S | ||||||||
| ACT_SITE | 96 | 96 | /note="Electrophile" | H | ||||||||
| ACT_SITE | 144 | 144 | /note="Proton acceptor" | E | ||||||||
| BINDING | 149 | 149 | /ligand="substrate" | I | ||||||||
| BINDING | 184 | 184 | /ligand="substrate" | G | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 213-231 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_00145 (pgk) Cter: None |
| Comments | Probable wrong start in CHLTR |