HAMAP

Accession	MF_00148
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00148; [distribution of match scores in UniProtKB];[seed alignment for MF_00148]

Names

UDG

Identifier

UNG

Protein name

RecName: Full=Uracil-DNA glycosylase; Short=UDG; EC=3.2.2.27;

Gene name

ung

FUNCTION: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).

CATALYTIC ACTIVITY: Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the uracil-DNA glycosylase family.

Pfam	PF03167; UDG; 1;
TIGRFAMs	TIGR00628; Ung; 1;
PROSITE	PS00130; U_DNA_GLYCOSYLASE; 1;

Cytoplasm, DNA damage, DNA repair, Hydrolase, Glycosidase.

GO:0004844; Molecular function: uracil DNA N-glycosylase activity.
GO:0006284; Biological process: base-excision repair.
GO:0005737; Cellular component: cytoplasm.

From: UNG_ECOLI (P12295)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		64		64		Proton acceptor (By similarity)		D

Size range:	212-266 amino acids
Related UniRules:	None
Template:	P12295 (UNG_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in LISIN, LISMO, STRCO
Plasmid encoded:	None
Comments:	Probable wrong start in RALSO. Weird insert in CORGL; not shown in alignment.