HAMAP annotation rule MF_00150
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Accession MF_00150
Dates 1-JUN-2001 (Created)
16-AUG-2010 (Last updated, Version 38)
Name ArgC_type1
Scope Bacteria
Archaea
Triggered by



Identifier
ARGC
case not <OC:Deinococci> and not <OC:Pyrococcus> and not <OC:Crenarchaeota>
Protein name
RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase;
Short=AGPR;
EC=1.2.1.38;
AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase;
Short=NAGSA dehydrogenase;
Gene name
argC
end case
case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
Protein name
RecName: Full=N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase;
Short=AGPR;
EC=1.2.1.-;
EC=1.2.1.38;
AltName: Full=N-acetyl-glutamate semialdehyde/N-acetyl-aminoadipate semialdehyde dehydrogenase;
Short=NAGSA dehydrogenase;
Gene name
argC, lysY
end case


case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
FUNCTION Involved in both the arginine and lysine biosynthetic pathways (By similarity).
end case
CATALYTIC ACTIVITY N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.
case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
CATALYTIC ACTIVITY N(2)-acetyl-L-aminoadipate-semialdehyde + NADP(+) + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH.
end case
PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate; step 3/4.
case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route); step 3/5.
end case
SUBCELLULAR LOCATION Cytoplasm (By similarity).
SIMILARITY Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.


Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
Lysine biosynthesis
end case
Oxidoreductase
NADP


GO:0003942; Molecular function: N-acetyl-gamma-glutamyl-phosphate reductase activity.
GO:0006526; Biological process: arginine biosynthetic process.
case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
GO:0009085; Biological process: lysine biosynthetic process.
end case
GO:0005737; Cellular component: cytoplasm.


Pfam PF01118; Semialdhyde_dh; 1;
PROSITE PS01224; ARGC; 1;


From: ARGC_ECOLI (P11446)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     154     154       By similarity     C  


Size range: 308-364 amino acids
Related Rules: MF_01110 (ARGC)
Templates: P11446 (ARGC_ECOLI); Q980X1 (ARGC_SULSO): [Recover all]
Fusion: None


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