HAMAP rule MF_00150

General rule information [?]

Accession	MF_00150
Dates	1-JUN-2001 (Created) 2-SEP-2024 (Last updated, Version 45)
Name	ArgC_type1
Scope(s)	Bacteria Archaea
Template(s)	P11446 (ARGC_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00150 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ARGC
Protein name	RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase; Short=AGPR; EC=1.2.1.38; AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase; Short=NAGSA dehydrogenase;
Gene name	Name=argC;

Comments [?]

FUNCTION	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
CATALYTIC ACTIVITY	Reaction=N-acetyl-L-glutamate 5-semialdehyde + phosphate + NADP(+) = N- acetyl-L-glutamyl 5-phosphate + NADPH + H(+); Xref=Rhea:RHEA:21588, ChEBI:CHEBI:15378, ChEBI:CHEBI:29123, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:57936, ChEBI:CHEBI:58349; EC=1.2.1.38;
PATHWAY	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 3/4.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003942; Molecular function:N-acetyl-gamma-glutamyl-phosphate reductase activity

GO:0006526; Biological process:arginine biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: ARGC_ECOLI (P11446)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

154

Additional information [?]

Size range	308-364 amino acids
Related rules	MF_02083
Fusion	Nter: None Cter: None
Comments	See MF_01110 for ArgC type 2 subfamily. MF_00150 also matches LysY, which is a subfamily of ArgC type 1. MF_02083 is a child of MF_00150 and is specific for LysY.