HAMAP rule MF_00151
General rule information
[?]
| Accession | MF_00151 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | PPAT_bact |
| Scope(s) |
Bacteria |
| Template(s) | P0A6I6 (COAD_ECOLI); O26010 (COAD_HELPY); P9WPA5 (COAD_MYCTU); P63820 (COAD_STAAW); Q8DNE6 (COAD_STRR6); O34797 (COAD_BACSU); Q3JW91 (COAD_BURP1); Q831P9 (COAD_ENTFA); B7V2S6 (COAD_PSEA8); P63819 (COAD_STAAN); Q9WZK0 (COAD_THEMA); Q5SJS9 (COAD_THET8); Q8ZJN9 (COAD_YERPE); [ Recover all ] |
| Triggered by |
HAMAP; MF_00151 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | COAD |
| Protein name | RecName: Full=Phosphopantetheine adenylyltransferase; EC=2.7.7.3; AltName: Full=Dephospho-CoA pyrophosphorylase; AltName: Full=Pantetheine-phosphate adenylyltransferase; Short=PPAT; |
| Gene name | Name=coaD; |
Comments
[?]
| FUNCTION | Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. |
| CATALYTIC ACTIVITY | Reaction=(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate; Xref=Rhea:RHEA:19801, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57328, ChEBI:CHEBI:61723; EC=2.7.7.3; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 4/5. |
| SUBUNIT | Homohexamer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the bacterial CoaD family. |
Keywords
[?]
| ATP-binding |
| Coenzyme A biosynthesis |
| Cytoplasm |
| Magnesium |
| Nucleotide-binding |
| Nucleotidyltransferase |
| Transferase |
Gene Ontology
[?]
| GO:0004595; Molecular function:pantetheine-phosphate adenylyltransferase activity |
| GO:0015937; Biological process:coenzyme A biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
| Pfam | PF01467; CTP_transf_2; 1; |
| PRINTS | PR01020; LPSBIOSNTHSS; 1; |
| NCBIfam | TIGR01510; CoaD_prev_kdtB; 1; |
| NCBIfam | TIGR00125; Cyt_tran_rel; 1; |
Features
[?]
| From: COAD_ECOLI (P0A6I6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS]-[FYL] | ||||||||
| BINDING | 89 | 91 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-R | ||||||||
| BINDING | 124 | 130 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 10 | 10 | /ligand="substrate" | [TS] | ||||||||
| BINDING | 18 | 18 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
H | ||||||||
| BINDING | 42 | 42 | /ligand="substrate" | K | ||||||||
| BINDING | 74 | 74 | /ligand="substrate" | [MLVIATS] | ||||||||
| BINDING | 88 | 88 | /ligand="substrate" | [RK] | ||||||||
| BINDING | 99 | 99 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E | ||||||||
| SITE | 18 | 18 | /note="Transition state stabilizer" | H | ||||||||
Additional information
[?]
| Size range | 140-191 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in ZYMMO |