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HAMAP annotation rule: MF_00154
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General rule information

Accession MF_00154
Dates 1-JUN-2001 (Created)
27-JUN-2011 (Last updated, Version 36)
Data class Protein
Predictors HAMAP; MF_00154; [distribution of match scores in UniProtKB];[seed alignment for MF_00154]
Names CyoE_CtaB


Propagated annotation

Identifier, protein and gene names

case <OC:Gammaproteobacteria>
Identifier CYOE

else
Identifier COXX
end case

Protein name
RecName: Full=Protoheme IX farnesyltransferase;
EC=2.5.1.-;
AltName: Full=Heme B farnesyltransferase;
AltName: Full=Heme O synthase;

case <OC:Gammaproteobacteria>
Gene name cyoE

else
Gene name ctaB
end case

Comments
FUNCTION: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity).
PATHWAY: Porphyrin metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.

case <OC:Firmicutes> or <OC:Rhodobacterales>
SUBUNIT: Interacts with CtaA (By similarity).
end case


case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (Potential).
end case

MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature (By similarity).
SIMILARITY: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
Cross-references
Pfam PF01040; UbiA; 1;
PF02628; COX15-CtaA; 1;
TIGRFAMs TIGR01473; CyoE_ctaB; 1;
PROSITE PS00943; UBIA; 1;
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
General Transmembrane; -; 0-9; trigger=Yes;
end case

Keywords

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Cell membrane, Heme biosynthesis, Membrane, Transferase, Transmembrane, Transmembrane helix.
Gene Ontology
GO:0008495; Molecular function: protoheme IX farnesyltransferase activity.
GO:0048034; Biological process: heme O biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Features

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
From: CYOE_ECOLI (P0AEA5)
Key     From     To       Description   Condition   FTGroup
TOPO_DOM     Nter     9       Cytoplasmic (Potential)      
TRANSMEM     10     28       Helical; (Potential)      
TOPO_DOM     29     37       Periplasmic (Potential)      
TRANSMEM     38     56       Helical; (Potential)      
TOPO_DOM     57     78       Cytoplasmic (Potential)      
TRANSMEM     79     97       Helical; (Potential)      
TOPO_DOM     98     107       Periplasmic (Potential)      
TRANSMEM     108     126       Helical; (Potential)      
TOPO_DOM     127     197       Cytoplasmic (Potential)      
TRANSMEM     198     216       Helical; (Potential)      
TOPO_DOM     217     228       Periplasmic (Potential)      
TRANSMEM     229     247       Helical; (Potential)      
TOPO_DOM     248     268       Cytoplasmic (Potential)      
TRANSMEM     269     287       Helical; (Potential)      
TOPO_DOM     288     Cter       Periplasmic (Potential)      
end case



Additional information

Size range: 259-345 amino acids
Related UniRules: None
Template: P24009 (COXX2_BACSU); O31652 (COXX1_BACSU); P0AEA5 (CYOE_ECOLI); Q3J5F9 (COXX_RHOS4): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: <Unknown>, <COX15-CtaA>; Cter: <Prenyltransferase>
Duplicate: in BACA2, BACCN, BACSU, CENSY, CHRVO, LYSSC, MAGSA, NATPD, NITWN, PICTO, PSEA6, PSEA7, PSEAB, PSEAE, PSEE4, PSEF5, PSEHT, PSEP1, PSEPF, PSEPG, PSEPK, PSEPW, PYRAE, PYRCJ, RHILO, SACEN, SHEB8, SHEB9, SHEFN, SHELP, SHEPC, SHESA, SHESM, SHESR, SHESW, SHEWM, VIBHB, VIBPA
Plasmid encoded: None
Comments: Possible wrong start in RHOSH

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UniProtKB rule member sequences