Due to maintenance work, this service will be unavailable from
Mon Nov 11 17:30 until
Tue Nov 12 09:00
CET.
Apologies for the inconvenience.
HAMAP rule MF_00158
General rule information
[?]
| Accession | MF_00158 |
| Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 35) |
| Name | PanC |
| Scope(s) |
Bacteria |
| Template(s) | P31663 (PANC_ECOLI); P9WIL5 (PANC_MYCTU); Q9X713 (PANC_CORGL); [ Recover all ] |
| Triggered by |
HAMAP; MF_00158 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | PANC |
| Protein name | RecName: Full=Pantothenate synthetase; Short=PS; EC=6.3.2.1; AltName: Full=Pantoate--beta-alanine ligase; AltName: Full=Pantoate-activating enzyme; |
| Gene name | Name=panC; |
Comments
[?]
| FUNCTION | Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. |
| CATALYTIC ACTIVITY | Reaction=(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10912, ChEBI:CHEBI:15378, ChEBI:CHEBI:15980, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:456215; EC=6.3.2.1; |
| PATHWAY | Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)- pantothenate from (R)-pantoate and beta-alanine: step 1/1. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| MISCELLANEOUS | The reaction proceeds by a bi uni uni bi ping pong mechanism. |
| SIMILARITY | Belongs to the pantothenate synthetase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0004592; Molecular function:pantoate-beta-alanine ligase activity |
| GO:0015940; Biological process:pantothenate biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Features
[?]
| From: PANC_MYCTU (P9WIL5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 40 | 47 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
M-x(3)-H-x(2)-H | ||||||||
| BINDING | 158 | 161 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x(2)-D | ||||||||
| BINDING | 195 | 198 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
x(3)-R | ||||||||
| ACT_SITE | 47 | 47 | /note="Proton donor" | H | ||||||||
| BINDING | 72 | 72 | /ligand="beta-alanine" /ligand_id="ChEBI:CHEBI:57966" |
Q | ||||||||
| BINDING | 72 | 72 | /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980" |
Q | ||||||||
| BINDING | 164 | 164 | /ligand="(R)-pantoate" /ligand_id="ChEBI:CHEBI:15980" |
Q | ||||||||
| BINDING | 187 | 187 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[VLIGA] | ||||||||
Additional information
[?]
| Size range | 251-337 amino acids |
| Related rules |
MF_01349 |
| Fusion | Nter: None Cter: None |
| Comments | In Cyanobacteriota this protein is fused C-terminally to cytidylate kinase (see Bifunctional pantoate ligase/cytidylate kinase MF_01349). Possible sequence error in STRCO; weird insertion; not shown in alignment. |