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HAMAP rule MF_00161

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General rule information [?]

Accession MF_00161
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43)
Name LspA
Scope(s) Bacteria
Template(s) P00804 (LSPA_ECOLI); Q45479 (LSPA_BACSU); Q9HVM5 (LSPA_PSEAE); Q2FHP2 (LSPA_STAA3); [ Recover all ]
Triggered by HAMAP; MF_00161 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LSPA
Protein name RecName: Full=Lipoprotein signal peptidase;
                 EC=3.4.23.36;
AltName: Full=Prolipoprotein signal peptidase;
AltName: Full=Signal peptidase II;
                 Short=SPase II;
Gene name Name=lspA;

Comments [?]

FUNCTIONThis protein specifically catalyzes the removal of signal peptides from prolipoproteins.
CATALYTIC ACTIVITY Reaction=Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.; EC=3.4.23.36;
PATHWAYProtein modification; lipoprotein biosynthesis (signal peptide cleavage).
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the peptidase A8 family.

Keywords [?]

Hydrolase
Protease
Aspartyl protease
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0004190; Molecular function:aspartic-type endopeptidase activity
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01252; Peptidase_A8; 1;
PRINTS PR00781; LIPOSIGPTASE; 1;
NCBIfam TIGR00077; LspA; 1;
PROSITE PS00855; SPASE_II; 1;
General Transmembrane; -; 4-5;

Features [?]

From: LSPA_PSEAE (Q9HVM5)
Key From To Description Tag Condition FTGroup
ACT_SITE 124 124 D
ACT_SITE 143 143 D

Additional information [?]

Size range 145-304 amino acids
Related rules None
Fusion Nter: <Unknown> Cter: None



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