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| HAMAP annotation rule MF_00161 |
| Accession |
MF_00161 |
| Dates |
1-JUN-2001 (Created)
18-MAY-2011 (Last updated, Version 38) |
| Protein name |
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RecName:
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Full=Lipoprotein signal peptidase;
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EC=3.4.23.36;
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AltName:
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Full=Prolipoprotein signal peptidase;
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AltName:
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Full=Signal peptidase II;
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Short=SPase II;
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| FUNCTION |
This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity). |
| CATALYTIC ACTIVITY |
Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. |
| PATHWAY |
Protein modification; lipoprotein biosynthesis (signal peptide cleavage). |
case not defined <Property:Membrane> or <Property:Membrane=1>
| SUBCELLULAR LOCATION |
Cell membrane; Multi-pass membrane protein (By similarity). |
else case <Property:Membrane=2>
| SUBCELLULAR LOCATION |
Cell inner membrane; Multi-pass membrane protein (By similarity). |
end case
| SIMILARITY |
Belongs to the peptidase A8 family. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0004190; Molecular function: aspartic-type endopeptidase activity.
GO:0005886; Cellular component: plasma membrane.
| General |
Transmembrane; -; 4-5; trigger=yes; |
| From: LSPA_ECOLI (P00804) |
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Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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114
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114
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By similarity
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D
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ACT_SITE
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141
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141
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By similarity
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D
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| Size range: |
145-304 amino acids |
| Related Rules: |
None |
| Templates: |
P00804 (LSPA_ECOLI); Q45479 (LSPA_BACSU): [Recover all] |
| Fusion: |
Nter: <Unknown>; Cter: None |