HAMAP rule MF_00162
General rule information
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Accession | MF_00162 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 26) |
Name | GSH_S |
Scope(s) |
Bacteria |
Template(s) | P04425 (GSHB_ECOLI); O32463 (GSHB_SYNE7); [ Recover all ] |
Triggered by |
HAMAP; MF_00162 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GSHB |
Protein name | RecName: Full=Glutathione synthetase; EC=6.3.2.3; AltName: Full=GSH synthetase; Short=GSH-S; Short=GSHase; AltName: Full=Glutathione synthase; |
Gene name | Name=gshB; |
Comments
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CATALYTIC ACTIVITY | Reaction=ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate; Xref=Rhea:RHEA:13557, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.3; |
PATHWAY | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. |
SIMILARITY | Belongs to the prokaryotic GSH synthase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0004363; Molecular function:glutathione synthase activity |
GO:0006750; Biological process:glutathione biosynthetic process |
Cross-references
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Pfam | PF02955; GSH-S_ATP; 1; |
Pfam | PF02951; GSH-S_N; 1; |
PROSITE | PS50975; ATP_GRASP; 1; |
NCBIfam | TIGR01380; glut_syn; 1; |
Features
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Additional information
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Size range | 307-324 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |