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HAMAP annotation rule: MF_00164
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General rule information

Accession MF_00164
Dates 1-JUN-2001 (Created)
18-MAY-2011 (Last updated, Version 37)
Data class Protein
Predictors HAMAP; MF_00164; [distribution of match scores in UniProtKB];[seed alignment for MF_00164]
Names GlmS


Propagated annotation

Identifier, protein and gene names
Identifier GLMS
Protein name
RecName: Full=Glucosamine--fructose-6-phosphate aminotransferase [isomerizing];
EC=2.6.1.16;
AltName: Full=D-fructose-6-phosphate amidotransferase;
AltName: Full=GFAT;
AltName: Full=Glucosamine-6-phosphate synthase;
AltName: Full=Hexosephosphate aminotransferase;
AltName: Full=L-glutamine-D-fructose-6-phosphate amidotransferase;
Gene name glmS
Comments
FUNCTION: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity).
CATALYTIC ACTIVITY: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
SUBUNIT: Homodimer (By similarity).

case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast.
end case


case not <OG:Chloroplast>
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
end case

Cross-references
Pfam PF00310; GATase_2; 1;
PF01380; SIS; 2;
TIGRFAMs TIGR01135; GlmS; 1;
PROSITE PS51278; GATASE_TYPE_2; 1; trigger=PRU00609;
PS51464; SIS; 1-2; trigger=PRU00797;
Keywords

case not <OG:Chloroplast>
Cytoplasm.
end case

Transferase, Aminotransferase.
Gene Ontology
GO:0004360; Molecular function: glutamine-fructose-6-phosphate transaminase (isomerizing) activity.
GO:0005975; Biological process: carbohydrate metabolic process.

case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case


case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case

Features
From: GLMS_ECOLI (P17169)
Key     From     To       Description   Condition   FTGroup
INIT_MET     1     1       Removed (By similarity)   M  
ACT_SITE     2     2       Nucleophile; for GATase activity (By similarity)   C  
ACT_SITE     604     604       For Fru-6P isomerization activity (By similarity)   K  


Additional information

Size range: 589-635 amino acids
Related UniRules: None
Template: P17169 (GLMS_ECOLI); Q56213 (GLMS_THET8); Q6LWM9 (GLMS_METMP): [Recover all]
Scope: Bacteria
Archaea
Plastid
Fusion: Nter: None; Cter: None
Duplicate: in RHIME
Plasmid encoded: in RHILV, RHIME
Comments: Nodulating bacteria seem to have two copies: a glmS and a nodM. There does not seem to be any mean of distinguishing the two forms. Intein deleted in METJA (not shown in alignment).

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UniProtKB rule member sequences