HAMAP rule MF_00165
General rule information
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| Accession | MF_00165 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 29) |
| Name | Thymidylate_kinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A720 (KTHY_ECOLI); P9WKE1 (KTHY_MYCTU); O69169 (KTHY_YERPE); [ Recover all ] |
| Triggered by |
HAMAP; MF_00165 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KTHY |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Thymidylate kinase; EC=2.7.4.9; AltName: Full=dTMP kinase; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable thymidylate kinase; EC=2.7.4.9; AltName: Full=dTMP kinase; |
| end case | |
| Gene name | Name=tmk; |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517, ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.4.9; |
| SIMILARITY | Belongs to the thymidylate kinase family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0004798; Molecular function:thymidylate kinase activity |
| GO:0006235; Biological process:dTTP biosynthetic process |
Cross-references
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| Pfam | PF02223; Thymidylate_kin; 1; |
| NCBIfam | TIGR00041; DTMP_kinase; 1; |
| PROSITE | PS01331; THYMIDYLATE_KINASE; 1; |
Features
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| From: KTHY_ECOLI (P0A720) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 17 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-[DE]-[GACT]-x-G-K-[ST] | ||||||||
Additional information
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| Size range | 188-245 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible inactive tmk in AERPE and TREPA due to a defective ATP-binding site; not shown in alignment. Possible wrong start in RHOBA. |