HAMAP annotation rule MF_00165
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Accession MF_00165
Dates 1-JUN-2001 (Created)
4-FEB-2010 (Last updated, Version 21)
Name Thymidylate_kinase
Scope Bacteria
Archaea
Triggered by



Identifier
KTHY
case <OC:Bacteria>
Protein name
RecName: Full=Thymidylate kinase;
EC=2.7.4.9;
AltName: Full=dTMP kinase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable thymidylate kinase;
EC=2.7.4.9;
AltName: Full=dTMP kinase;
end case
Gene name
tmk


case <OC:Bacteria>
FUNCTION Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
end case
CATALYTIC ACTIVITY ATP + dTMP = ADP + dTDP.
SIMILARITY Belongs to the thymidylate kinase family.


Transferase
Kinase
Nucleotide biosynthesis
ATP-binding
Nucleotide-binding


GO:0005524; Molecular function: ATP binding.
GO:0004798; Molecular function: thymidylate kinase activity.
GO:0006235; Biological process: dTTP biosynthetic process.


Pfam PF02223; Thymidylate_kin; 1;
TIGRFAMs TIGR00041; DTMP_kinase; 1;
PROSITE PS01331; THYMIDYLATE_KINASE; 1;


From: KTHY_ECOLI (P0A720)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     10     17       ATP (Potential)     G-x-[DE]-[GACT]-x-G-K-[ST]  


Size range: 188-245 amino acids
Related Rules: None
Templates: P0A720 (KTHY_ECOLI); O05891 (KTHY_MYCTU); O69169 (KTHY_YERPE): [Recover all]
Fusion: None
Comments: Possible inactive tmk in AERPE and TREPA due to a defective ATP-binding site; not shown in alignment. Possible wrong start in RHOBA.


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