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HAMAP annotation rule: MF_00165
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General rule information

Accession MF_00165
Dates 1-JUN-2001 (Created)
4-FEB-2010 (Last updated, Version 21)
Data class Protein
Predictors HAMAP; MF_00165; [distribution of match scores in UniProtKB];[seed alignment for MF_00165]
Names Thymidylate_kinase


Propagated annotation

Identifier, protein and gene names
Identifier KTHY

case <OC:Bacteria>
Protein name
RecName: Full=Thymidylate kinase;
EC=2.7.4.9;
AltName: Full=dTMP kinase;
end case


case <OC:Archaea>
Protein name
RecName: Full=Probable thymidylate kinase;
EC=2.7.4.9;
AltName: Full=dTMP kinase;
end case

Gene name tmk
Comments

case <OC:Bacteria>
FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
end case

CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
SIMILARITY: Belongs to the thymidylate kinase family.
Cross-references
Pfam PF02223; Thymidylate_kin; 1;
TIGRFAMs TIGR00041; DTMP_kinase; 1;
PROSITE PS01331; THYMIDYLATE_KINASE; 1;
Keywords
Transferase, Kinase, Nucleotide biosynthesis, ATP-binding, Nucleotide-binding.
Gene Ontology
GO:0005524; Molecular function: ATP binding.
GO:0004798; Molecular function: thymidylate kinase activity.
GO:0006235; Biological process: dTTP biosynthetic process.
Features
From: KTHY_ECOLI (P0A720)
Key     From     To       Description   Condition   FTGroup
NP_BIND     10     17       ATP (Potential)   G-x-[DE]-[GACT]-x-G-K-[ST]  


Additional information

Size range: 188-245 amino acids
Related UniRules: None
Template: P0A720 (KTHY_ECOLI); O05891 (KTHY_MYCTU); O69169 (KTHY_YERPE): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in SULSO, SULTO
Plasmid encoded: None
Comments: Possible inactive tmk in AERPE and TREPA due to a defective ATP-binding site; not shown in alignment. Possible wrong start in RHOBA.

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UniProtKB rule member sequences