HAMAP rule MF_00167
General rule information
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Accession | MF_00167 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 23) |
Name | CsrA |
Scope(s) |
Bacteria |
Template(s) | P69913 (CSRA_ECOLI); P33911 (CSRA_BACSU); O69078 (CSRA_PSEAE); P0DPC3 (CSRA1_PSEPH); [ Recover all ] |
Triggered by |
HAMAP; MF_00167 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | CSRA |
case <OC:Gammaproteobacteria> | |
Protein name | RecName: Full=Translational regulator CsrA; AltName: Full=Carbon storage regulator; |
else | |
Protein name | RecName: Full=Translational regulator CsrA; |
end case | |
Gene name | Name=csrA; |
Comments
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case <OC:Gammaproteobacteria> | |
FUNCTION | A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). |
else | |
FUNCTION | A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. |
end case | |
SUBUNIT | Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the CsrA/RsmA family. |
Keywords
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case <OC:Gammaproteobacteria> | |
Activator | |
end case | |
case not <OC:Gammaproteobacteria> | |
Bacterial flagellum biogenesis | |
end case | |
Cytoplasm | |
Repressor | |
RNA-binding | |
Translation regulation |
Gene Ontology
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GO:0005737; Cellular component:cytoplasm | |
GO:0048027; Molecular function:mRNA 5'-UTR binding | |
GO:0045947; Biological process:negative regulation of translational initiation | |
case <OCellular component:Gammaproteobacteria> | |
GO:0006109; Biological process:regulation of carbohydrate metabolic process | |
GO:0045948; Biological process:positive regulation of translational initiation | |
end case | |
case not <OCellular component:Gammaproteobacteria> | |
GO:1902208; Biological process:regulation of bacterial-type flagellum assembly | |
end case |
Cross-references
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Features
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Additional information
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Size range | 57-135 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | The ancestral operon is thought to be Fliw-CsrA, where CsrA is dedicated to controlling flagellar assembly and motility. Rounds of gene loss and re-acquisition in Gammaproteobacteria have lead to CsrA being repurposed for a larger role in translation control. See PubMed:25833324, Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review. |