HAMAP

Accession	MF_00169
Dates	1-JUN-2001 (Created) 18-MAY-2011 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00169; [distribution of match scores in UniProtKB];[seed alignment for MF_00169]

Names

AroQ

Identifier

AROQ

Protein name

RecName: Full=3-dehydroquinate dehydratase; Short=3-dehydroquinase; EC=4.2.1.10; AltName: Full=Type II DHQase;

Gene name

aroQ

FUNCTION: Catalyzes a trans-dehydration via an enolate intermediate (By similarity).

CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.

PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

SUBUNIT: Homododecamer (By similarity).

SIMILARITY: Belongs to the type-II 3-dehydroquinase family.

Pfam	PF01220; DHquinase_II; 1;
TIGRFAMs	TIGR01088; AroQ; 1;
PROSITE	PS01029; DEHYDROQUINASE_II; 1;

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Lyase.

GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

From: AROQ_STRCO (P15474)
Key		From		To		Description		Condition		FTGroup
REGION		108		109		Substrate binding (By similarity)		[LIVM]-[ST]
ACT_SITE		29		29		Proton acceptor (By similarity)		Y
ACT_SITE		107		107		Proton donor (By similarity)		H
BINDING		80		80		Substrate (By similarity)		N
BINDING		86		86		Substrate (By similarity)		H
BINDING		93		93		Substrate (By similarity)		D
BINDING		118		118		Substrate (By similarity)		R
SITE		24		24		Transition state stabilizer (By similarity)		R

Size range:	143-170 amino acids
Related UniRules:	None
Template:	P15474 (AROQ_STRCO); Q48255 (AROQ_HELPY); P0A4Z6 (AROQ_MYCTU); P46380 (AROQ_AMYME); P54517 (AROQ_BACSU); P43877 (AROQ_ACTPL): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in AGRT5, BRAJA, COREF, PSEAE, PSEPK, RALSO
Plasmid encoded:	in RALSO
Comments:	There are two type of DHQases, B.subtilis seems to have both