HAMAP annotation rule MF_00172
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Accession MF_00172
Dates 1-JUN-2001 (Created)
18-MAY-2011 (Last updated, Version 25)
Name Meth_synth
Scope Bacteria
Triggered by



Identifier
METE
Protein name
RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase;
EC=2.1.1.14;
AltName: Full=Cobalamin-independent methionine synthase;
AltName: Full=Methionine synthase, vitamin-B12 independent isozyme;
Gene name
metE


FUNCTION Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
CATALYTIC ACTIVITY 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.
COFACTOR Binds 1 zinc ion per subunit (By similarity).
PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route); step 1/1.
SIMILARITY Belongs to the vitamin-B12 independent methionine synthase family.


Transferase
Methyltransferase
Amino-acid biosynthesis
Methionine biosynthesis
Metal-binding
Zinc
Repeat


GO:0003871; Molecular function: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.


Pfam PF08267; Meth_synt_1; 1;
PF01717; Meth_synt_2; 1;
PIRSF PIRSF000382; MeTrfase_B12_ind; 1;
TIGRFAMs TIGR01371; Met_syn_B12ind; 1;


From: METE_ECOLI (P25665)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     641     641       Zinc (By similarity)     H  
METAL     643     643       Zinc (By similarity)     C  
METAL     726     726       Zinc (By similarity)     C  


Size range: 734-792 amino acids
Related Rules: MF_00288 (METE)
Template: P25665 (METE_ECOLI)
Fusion: None


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