HAMAP

Accession	MF_00172
Dates	1-JUN-2001 (Created) 18-MAY-2011 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00172; [distribution of match scores in UniProtKB];[seed alignment for MF_00172]

Names

Meth_synth

Identifier

METE

Protein name

RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14; AltName: Full=Cobalamin-independent methionine synthase; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme;

Gene name

metE

FUNCTION: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).

CATALYTIC ACTIVITY: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase family.

Pfam	PF08267; Meth_synt_1; 1; PF01717; Meth_synt_2; 1;
PIRSF	PIRSF000382; MeTrfase_B12_ind; 1;
TIGRFAMs	TIGR01371; Met_syn_B12ind; 1;

Transferase, Methyltransferase, Amino-acid biosynthesis, Methionine biosynthesis, Metal-binding, Zinc, Repeat.

GO:0003871; Molecular function: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.

From: METE_ECOLI (P25665)
Key		From		To		Description		Condition		FTGroup
METAL		641		641		Zinc (By similarity)		H
METAL		643		643		Zinc (By similarity)		C
METAL		726		726		Zinc (By similarity)		C

Size range:	734-792 amino acids
Related UniRules:	MF_00288 (METE)
Template:	P25665 (METE_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in RALSO