Annotation rule MF_00177
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General rule information [?]

Accession MF_00177
Dates 1-JUN-2001 (Created)
21-NOV-2011 (Last updated, Version 29)
Name Lys_tRNA_synth_class1
Scope Bacteria
Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYK
Protein name
RecName: Full=Lysine--tRNA ligase;
EC=6.1.1.6;
AltName: Full=Lysyl-tRNA synthetase;
Short=LysRS;
Gene name
lysS

Comments [?]

Catalytic activity ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
Subcellular location Cytoplasm (By similarity).
Similarity Belongs to the class-I aminoacyl-tRNA synthetase family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004824; Molecular function: lysine-tRNA ligase activity.
GO:0006430; Biological process: lysyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01921; tRNA-synt_1f; 1;
TIGRFAMs TIGR00467; LysS_arch; 1;
PROSITE PS00178; AA_TRNA_LIGASE_I; 1;

Features [?]

From: SYK_RICPR (Q9ZDF8)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     44     52       "HIGH" region     [AIPTV]-S-G-x-[ILPQV]-H-[ILMV]-G-[HNRST]  
MOTIF     290     294       "KMSKS" region     [ADKP]-[FILM]-[HKS]-[GKS]-S  
BINDING     293     293       ATP (By similarity)     K  

Additional information [?]

Size range 493-580 amino acids
Related rules None
Templates O57963 (SYK_PYRHO); O51603 (SYK_BORBU); P0CW67 (SYK_METMP): [Recover all]
Fusion None
Comments Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both.