HAMAP

Accession	MF_00177
Dates	1-JUN-2001 (Created) 21-NOV-2011 (Last updated, Version 29)

Data class

Protein

Predictors

HAMAP; MF_00177; [distribution of match scores in UniProtKB];[seed alignment for MF_00177]

Names

Lys_tRNA_synth_class1

Identifier

SYK

Protein name

RecName: Full=Lysine--tRNA ligase; EC=6.1.1.6; AltName: Full=Lysyl-tRNA synthetase; Short=LysRS;

Gene name

lysS

CATALYTIC ACTIVITY: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.

Pfam	PF01921; tRNA-synt_1f; 1;
TIGRFAMs	TIGR00467; LysS_arch; 1;
PROSITE	PS00178; AA_TRNA_LIGASE_I; 1;

Cytoplasm, Aminoacyl-tRNA synthetase, Protein biosynthesis, Ligase, ATP-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0004824; Molecular function: lysine-tRNA ligase activity.
GO:0006430; Biological process: lysyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

From: SYK_RICPR (Q9ZDF8)
Key		From		To		Description		Condition		FTGroup
MOTIF		44		52		"HIGH" region		[AIPTV]-S-G-x-[ILPQV]-H-[ILMV]-G-[HNRST]
MOTIF		290		294		"KMSKS" region		[ADKP]-[FILM]-[HKS]-[GKS]-S
BINDING		293		293		ATP (By similarity)		K

Size range:	493-580 amino acids
Related UniRules:	None
Template:	O57963 (SYK_PYRHO); O51603 (SYK_BORBU); P0CW67 (SYK_METMP): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both.