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| HAMAP annotation rule MF_00177 |
| Accession | MF_00177 |
| Dates | 1-JUN-2001 (Created) 21-NOV-2011 (Last updated, Version 29) |
| Name | Lys_tRNA_synth_class1 |
| Scope | Bacteria Archaea |
| Triggered by |
| Identifier |
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| Protein name |
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| Gene name |
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| CATALYTIC ACTIVITY | ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
| SUBCELLULAR LOCATION | Cytoplasm (By similarity). |
| SIMILARITY | Belongs to the class-I aminoacyl-tRNA synthetase family. |
GO:0005524; Molecular function: ATP binding.
GO:0004824; Molecular function: lysine-tRNA ligase activity.
GO:0006430; Biological process: lysyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0004824; Molecular function: lysine-tRNA ligase activity.
GO:0006430; Biological process: lysyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
| Pfam | PF01921; tRNA-synt_1f; 1; |
| TIGRFAMs | TIGR00467; LysS_arch; 1; |
| PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
| From: SYK_RICPR (Q9ZDF8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 44 | 52 | "HIGH" region | [AIPTV]-S-G-x-[ILPQV]-H-[ILMV]-G-[HNRST] | ||||||||
| MOTIF | 290 | 294 | "KMSKS" region | [ADKP]-[FILM]-[HKS]-[GKS]-S | ||||||||
| BINDING | 293 | 293 | ATP (By similarity) | K | ||||||||
| Size range: | 493-580 amino acids |
| Related Rules: | None |
| Templates: | O57963 (SYK_PYRHO); O51603 (SYK_BORBU); P0CW67 (SYK_METMP): [Recover all] |
| Fusion: | None |
| Comments: | Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both. |