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HAMAP rule MF_00177

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General rule information [?]

Accession MF_00177
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 36)
Name Lys_tRNA_synth_class1
Scope(s) Bacteria
Archaea
Template(s) O57963 (SYK_PYRHO); O51603 (SYK_BORBU); P0CW67 (SYK_METMP); [ Recover all ]
Triggered by HAMAP; MF_00177 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SYK
Protein name RecName: Full=Lysine--tRNA ligase;
                 EC=6.1.1.6;
AltName: Full=Lysyl-tRNA synthetase;
                 Short=LysRS;
Gene name Name=lysS;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl- tRNA(Lys); Xref=Rhea:RHEA:20792, Rhea:RHEA-COMP:9696, Rhea:RHEA- COMP:9697, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6;
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class-I aminoacyl-tRNA synthetase family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004824; Molecular function:lysine-tRNA ligase activity
GO:0006430; Biological process:lysyl-tRNA aminoacylation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01921; tRNA-synt_1f; 1;
NCBIfam TIGR00467; LysS_arch; 1;
PROSITE PS00178; AA_TRNA_LIGASE_I; 1;

Features [?]

From: SYK_RICPR (Q9ZDF8)
Key From To Description Tag Condition FTGroup
MOTIF 44 52 /note="'HIGH' region" [AIPTV]-S-G-x-[ILPQV]-H-[ILMV]-G-[HNRST]
MOTIF 290 294 /note="'KMSKS' region" [ADKP]-[FILM]-[HKS]-[GKS]-S
BINDING 293 293 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K

Additional information [?]

Size range 493-580 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both.



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