HAMAP

Accession	MF_00182
Dates	1-JUN-2001 (Created) 18-MAY-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00182; [distribution of match scores in UniProtKB];[seed alignment for MF_00182]

Names

Formyl_trans

Identifier

FMT

Protein name

RecName: Full=Methionyl-tRNA formyltransferase; EC=2.1.2.9;

Gene name

fmt

FUNCTION: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity).

CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H(2)O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

SIMILARITY: Belongs to the fmt family.

Pfam	PF02911; Formyl_trans_C; 1; PF00551; Formyl_trans_N; 1;
TIGRFAMs	TIGR00460; Fmt; 1;
PROSITE	PS00373; GART; 1;

Transferase, Methyltransferase, Protein biosynthesis.

GO:0004479; Molecular function: methionyl-tRNA formyltransferase activity.
GO:0006412; Biological process: translation.

From: FMT_ECOLI (P23882)
Key		From		To		Description		Condition		FTGroup
REGION		113		116		Tetrahydrofolate (THF) binding (By similarity)		[GS]-x-L-P

Size range:	289-342 amino acids
Related UniRules:	None
Template:	P23882 (FMT_ECOLI); O85732 (FMT_PSEAE); P43523 (FMT_THETH): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Divergent RALSO not shown in alignment