HAMAP

Accession	MF_00184
Dates	1-JUN-2001 (Created) 21-NOV-2011 (Last updated, Version 36)

Data class

Protein

Predictors

HAMAP; MF_00184; [distribution of match scores in UniProtKB];[seed alignment for MF_00184]

Names

Thr_tRNA_synth

Identifier

SYT

Protein name

RecName: Full=Threonine--tRNA ligase; EC=6.1.1.3; AltName: Full=Threonyl-tRNA synthetase; Short=ThrRS;

Gene name

thrS

CATALYTIC ACTIVITY: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.

Pfam	PF00587; tRNA-synt_2b; 1;
PRINTS	PR01047; TRNASYNTHTHR; 1;
TIGRFAMs	TIGR00418; ThrS; 1;
PROSITE	PS50862; AA_TRNA_LIGASE_II; 1;

Acetylation.

Aminoacyl-tRNA synthetase, ATP-binding, Cytoplasm, Ligase, Nucleotide-binding, Protein biosynthesis.

Metal-binding, Zinc.

GO:0005524; Molecular function: ATP binding.
GO:0004829; Molecular function: threonine-tRNA ligase activity.
GO:0006435; Biological process: threonyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

From: SYT_ECOLI (P0A8M3)
Key		From		To		Description		Condition		FTGroup
REGION		243		534		Catalytic
METAL		334		334		Zinc; catalytic (By similarity)		C		1
METAL		385		385		Zinc; catalytic (By similarity)		H		1
METAL		511		511		Zinc; catalytic (By similarity)		H		1

Key		From		To		Description		Condition		FTGroup
MOD_RES		286		286		N6-acetyllysine (By similarity)		K

Size range:	540-702 amino acids
Related UniRules:	None
Template:	P0A8M3 (SYT_ECOLI); P56881 (SYT_THET8): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in AERPE, BACSU
Plasmid encoded:	None
Comments:	There are two ThrRS in AERPE. The first one (APE_0809.1) is most similar to bacterial ThrRS but it lack the N-terminal domain. The second one (APE_0117.1) is most similar to archaeal ThrRS but lack the central domain