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HAMAP annotation rule: MF_00186
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General rule information

Accession MF_00186
Dates 1-JUN-2001 (Created)
18-MAY-2011 (Last updated, Version 27)
Data class Protein
Predictors HAMAP; MF_00186; [distribution of match scores in UniProtKB];[seed alignment for MF_00186]
Names Glycerol_kin


Propagated annotation

Identifier, protein and gene names
Identifier GLPK
Protein name
RecName: Full=Glycerol kinase;
EC=2.7.1.30;
AltName: Full=ATP:glycerol 3-phosphotransferase;
AltName: Full=Glycerokinase;
Short=GK;
Gene name glpK
Comments
FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism (By similarity).
CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-phosphate.
PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
SIMILARITY: Belongs to the FGGY kinase family.
Cross-references
PROSITE PS00933; FGGY_KINASES_1; 1;
PS00445; FGGY_KINASES_2; 1;
Pfam PF02782; FGGY_C; 1;
PF00370; FGGY_N; 1;
TIGRFAMs TIGR01311; Glycerol_kin; 1;
Keywords
Glycerol metabolism, Transferase, Kinase, ATP-binding, Nucleotide-binding.
Gene Ontology
GO:0005524; Molecular function: ATP binding.
GO:0004370; Molecular function: glycerol kinase activity.
GO:0006072; Biological process: glycerol-3-phosphate metabolic process.
Features
From: GLPK_ECOLI (P0A6F3)
Key     From     To       Description   Condition   FTGroup
NP_BIND     412     416       ATP (By similarity)      
BINDING     14     14       Substrate (By similarity)   [TS]  
BINDING     18     18       ATP (By similarity)   [RK]  
BINDING     84     84       Substrate (By similarity)   R  
BINDING     136     136       Substrate (By similarity)   Y  
BINDING     246     246       Substrate (By similarity)   D  
BINDING     268     268       ATP (By similarity)   T  
BINDING     311     311       ATP; via carbonyl oxygen (By similarity)   G  


Additional information

Size range: 490-517 amino acids
Related UniRules: None
Template: P0A6F3 (GLPK_ECOLI); P18157 (GLPK_BACSU); O34153 (GLPK_ENTCA); O34154 (GLPK_ENTFA); Q9WX53 (GLPK_THEAQ); O66131 (GLPK_THETH); O93623 (GLPK_PYRKO): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in CLOTE, LACPL, PSEAE, STRAW, STRCO, SULSO, THEMA
Plasmid encoded: in RHIME
Comments: Possible wrong start in RHOBA; sequence not included in alignment and not taken into account in size range. There is a possible divergent glpK in ARCFU: AF0866.

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UniProtKB rule member sequences