HAMAP

Accession	MF_00188
Dates	1-JUN-2001 (Created) 10-AUG-2010 (Last updated, Version 41)

Data class

Protein

Predictors

HAMAP; MF_00188; [distribution of match scores in UniProtKB];[seed alignment for MF_00188]

Names

Peptidase_M48

Identifier

HTPX

Protein name

RecName: Full=Protease HtpX; EC=3.4.24.-; AltName: Full=Heat shock protein HtpX;

Protein name

RecName: Full=Protease HtpX homolog; EC=3.4.24.-;

Gene name

htpX

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the peptidase M48B family.

Pfam	PF01435; Peptidase_M48; 1;
PROSITE	PS00142; ZINC_PROTEASE; 1;
General	Transmembrane; -; 3-5; trigger=Yes;

Stress response.

Cell inner membrane.

Cell membrane, Hydrolase, Membrane, Metal-binding, Metalloprotease, Protease, Transmembrane, Zinc, Transmembrane helix.

GO:0004222; Molecular function: metalloendopeptidase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0005886; Cellular component: plasma membrane.

From: HTPX_ECOLI (P23894)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		140		140		By similarity		E
METAL		139		139		Zinc; catalytic (By similarity)		H
METAL		143		143		Zinc; catalytic (By similarity)		H
METAL		222		222		Zinc; catalytic (By similarity)		E

Size range:	258-366 amino acids
Related UniRules:	None
Template:	P23894 (HTPX_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in METAC, METMA, STRCO, SULAC, SULSO, SULTO
Plasmid encoded:	None
Comments:	Possible wrong start in ARCFU and METTH. Possible C-terminal frameshift in METTH. Divergent duplicate htpX sequence in PYRHO: PH1588. Not induced by heat shock in Streptococcus gordonii.