HAMAP

Accession	MF_00190
Dates	1-JUN-2001 (Created) 13-JUL-2010 (Last updated, Version 32)

Data class

Protein

Predictors

HAMAP; MF_00190; [distribution of match scores in UniProtKB];[seed alignment for MF_00190]

Names

Cardiolipin_synth

Identifier

CLS

Protein name

RecName: Full=Cardiolipin synthase; Short=CL synthase; EC=2.7.8.-;

Gene name

cls

FUNCTION: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity).

CATALYTIC ACTIVITY: 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.

SIMILARITY: Contains 2 PLD phosphodiesterase domains.

Pfam	PF00614; PLDc; 1;
PROSITE	PS50035; PLD; 1; trigger=PRU00153;
General	Transmembrane; -; 2-3; trigger=Yes;

Cell inner membrane.

Cell membrane, Membrane, Transferase, Phospholipid biosynthesis, Transmembrane, Transmembrane helix.

GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

From: CLS_ECOLI (P0A6H8)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		224		224		Potential		H
ACT_SITE		404		404		Potential		H

Size range:	476-503 amino acids
Related UniRules:	None
Template:	P0A6H8 (CLS_ECOLI); O66043 (CLS_BACPE): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BACSU
Plasmid encoded:	None
Comments:	There is a third divergent cls-like protein in BACSU (ywjE) as well as cls- like proteins in E.coli (ybhO and ymdC) and H.pylori (HP0190)