To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_00198
Send feedback

General rule information [?]

Accession MF_00198
Dates 1-JUN-2001 (Created)
25-NOV-2014 (Last updated, Version 39)
Name Spermidine_synth
Scope Bacteria
Archaea
Templates P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY); O57950 (SPEE_PYRHO); Q9UXE4 (SPEE_SULSO); Q5JFG9 (SPEE_THEKO); Q5SK28 (SPEE_THET8): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SPEE
Protein name
RecName: Full=Polyamine aminopropyltransferase;
AltName: Full=Spermidine synthase;
Short=SPDSY;
Short=SPDS;
EC=2.5.1.16;
AltName: Full=Putrescine aminopropyltransferase;
Short=PAPT;
Gene name
speE

Comments [?]

Function Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Catalytic activity S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.
Pathway Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
case <Feature:Transmembrane>1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Feature:Transmembrane==1>
Subcellular location Cell membrane; Single-pass membrane protein.
else
Subcellular location Cytoplasm.
end case
Subunit Homodimer or homotetramer.
Similarity Belongs to the spermidine/spermine synthase family.
case not <FTTag:Act_site>
Caution Lacks the conserved Asp active site.
end case

Keywords [?]

case <Feature:Transmembrane>1>
else
end case

Gene Ontology [?]

GO:0004766; Molecular function: spermidine synthase activity.
GO:0008295; Biological process: spermidine biosynthetic process.

Cross-references [?]

Pfam PF01564; Spermine_synth; 1;
TIGRFAMs TIGR00417; SpeE; 1;
PROSITE PS01330; PABS_1; 1;
PS51006; PABS_2; 1; trigger=PRU00354;

Computed features [?]

General Transmembrane; -; 7; trigger=yes;

Features [?]

From: SPEE_PYRHO (O57950)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     52     53       Polyamine binding     [VIL]-Q  
REGION (Optional)     144     145       S-adenosylmethioninamine binding     [DNE]-[AGV]  
REGION (Optional)     162     164       Polyamine binding     [SC]-x-[DNE]  
ACT_SITE     161     161       Proton acceptor   Act_site   D  
BINDING (Optional)     8     8       Polyamine     [ED]  
BINDING (Optional)     32     32       S-adenosylmethioninamine     [QNR]  
BINDING (Optional)     63     63       Polyamine     H  
BINDING (Optional)     87     87       Polyamine     [DNE]  
BINDING (Optional)     107     107       S-adenosylmethioninamine     [ED]  
BINDING (Optional)     168     168       S-adenosylmethioninamine; via carbonyl oxygen     P  

Additional information [?]

Size range 261-574 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: <Unknown>