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HAMAP annotation rule: MF_00198
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General rule information

Accession MF_00198
Dates 1-JUN-2001 (Created)
4-JUL-2011 (Last updated, Version 31)
Data class Protein
Predictors HAMAP; MF_00198; [distribution of match scores in UniProtKB];[seed alignment for MF_00198]
Names Spermidine_synth


Propagated annotation

Identifier, protein and gene names
Identifier SPEE

case <OC:Bacteria>
Protein name
RecName: Full=Spermidine synthase;
EC=2.5.1.16;
AltName: Full=Putrescine aminopropyltransferase;
Short=PAPT;
AltName: Full=SPDSY;
end case


case <OC:Archaea>
Protein name
RecName: Full=Probable spermidine synthase;
EC=2.5.1.16;
AltName: Full=Putrescine aminopropyltransferase;
Short=PAPT;
AltName: Full=SPDSY;
end case

Gene name speE
Comments
FUNCTION: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity).
CATALYTIC ACTIVITY: S-adenosylmethioninamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.
PATHWAY: Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.

case <OC:Proteobacteria>
SUBUNIT: Homodimer and homotetramer (By similarity).
end case


case <OC:Thermotogales>
SUBUNIT: Homotetramer (By similarity).
end case


case not <OC:Proteobacteria> and not <OC:Thermotogales>
SUBUNIT: Homodimer or homotetramer (By similarity).
end case

SIMILARITY: Belongs to the spermidine/spermine synthase family.

case not <FTTag:Act_site>
CAUTION: Lacks the conserved Asp active site.
end case

Cross-references
Pfam PF01564; Spermine_synth; 1;
TIGRFAMs TIGR00417; SpeE; 1;
PROSITE PS01330; SPERMIDINE_SYNTHASE_1; 1;
PS51006; SPERMIDINE_SYNTHASE_2; 1;
Keywords
Polyamine biosynthesis, Spermidine biosynthesis, Transferase.
Gene Ontology
GO:0004766; Molecular function: spermidine synthase activity.
GO:0008295; Biological process: spermidine biosynthetic process.
Features
From: SPEE_ECOLI (P09158)
Key     From     To       Description   Condition   FTGroup
REGION (Optional)     140     141       S-adenosylmethioninamine binding (By similarity)   [DN]-[AGV]  
ACT_SITE     158     158       Proton acceptor (By similarity)   D  
BINDING (Optional)     33     33       S-adenosylmethioninamine (By similarity)   [QNR]  
BINDING (Optional)     63     63       Putrescine (By similarity)   Y  
BINDING (Optional)     88     88       S-adenosylmethioninamine (By similarity)   [DE]  
BINDING (Optional)     108     108       S-adenosylmethioninamine (By similarity)   [ED]  
BINDING (Optional)     161     161       Putrescine (By similarity)   [DENQ]  
BINDING (Optional)     226     226       Putrescine (By similarity)   Y  


Additional information

Size range: 261-366 amino acids
Related UniRules: None
Template: P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: <Unknown>; Cter: <Unknown>
Duplicate: in AQUAE, BACAN, BACCR, LEPIN, PSEAE, RALSO, STRCO, THETN
Plasmid encoded: in RALSO

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UniProtKB rule member sequences