Annotation rule MF_00198
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General rule information [?]

Accession MF_00198
Dates 1-JUN-2001 (Created)
16-JUN-2014 (Last updated, Version 36)
Name Spermidine_synth
Scope Bacteria
Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SPEE
Protein name
RecName: Full=Polyamine aminopropyl transferase;
AltName: Full=Spermidine synthase;
Short=SPDSY;
Short=SPDS;
EC=2.5.1.16;
AltName: Full=Putrescine aminopropyltransferase;
Short=PAPT;
Gene name
speE

Comments [?]

Function Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine (By similarity).
Catalytic activity S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.
Pathway Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine; step 1/1.
case <Feature:Transmembrane>1>
Subcellular location Cell membrane; Multi-pass membrane protein (By similarity).
else case <Feature:Transmembrane==1>
Subcellular location Cell membrane; Single-pass membrane protein (By similarity).
else
Subcellular location Cytoplasm (By similarity).
end case
Subunit Homodimer or homotetramer (By similarity).
Similarity Belongs to the spermidine/spermine synthase family.
case not <FTTag:Act_site>
Caution Lacks the conserved Asp active site.
end case

Keywords [?]

case <Feature:Transmembrane>1>
else
end case

Gene Ontology [?]

GO:0004766; Molecular function: spermidine synthase activity.
GO:0008295; Biological process: spermidine biosynthetic process.

Cross-references [?]

Pfam PF01564; Spermine_synth; 1;
TIGRFAMs TIGR00417; SpeE; 1;
PROSITE PS01330; PABS_1; 1;
PS51006; PABS_2; 1; trigger=PRU00354;

Computed features [?]

General Transmembrane; -; 7; trigger=yes;

Features [?]

From: SPEE_PYRHO (O57950)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     52     53       Polyamine binding (By similarity)     [VIL]-Q  
REGION (Optional)     144     145       S-adenosylmethioninamine binding (By similarity)     [DNE]-[AGV]  
REGION (Optional)     162     164       Polyamine binding (By similarity)     [SC]-x-[DNE]  
ACT_SITE     161     161       Proton acceptor (By similarity)   Act_site   D  
BINDING (Optional)     8     8       Polyamine (By similarity)     [ED]  
BINDING (Optional)     32     32       S-adenosylmethioninamine (By similarity)     [QNR]  
BINDING (Optional)     63     63       Polyamine (By similarity)     H  
BINDING (Optional)     87     87       Polyamine (By similarity)     [DNE]  
BINDING (Optional)     107     107       S-adenosylmethioninamine (By similarity)     [ED]  
BINDING (Optional)     168     168       S-adenosylmethioninamine; via carbonyl oxygen (By similarity)     P  

Additional information [?]

Size range 261-574 amino acids
Related rules None
Templates P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY); O57950 (SPEE_PYRHO); Q9UXE4 (SPEE_SULSO); Q5JFG9 (SPEE_THEKO); Q5SK28 (SPEE_THET8): [Recover all]
Fusion Nter: <Unknown>; Cter: <Unknown>