HAMAP annotation rule MF_00198
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Accession MF_00198
Dates 1-JUN-2001 (Created)
18-MAR-2013 (Last updated, Version 32)
Name Spermidine_synth
Scope Bacteria
Archaea
Triggered by



Identifier
SPEE
case <OC:Bacteria>
Protein name
RecName: Full=Spermidine synthase;
EC=2.5.1.16;
AltName: Full=Putrescine aminopropyltransferase;
Short=PAPT;
AltName: Full=SPDSY;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable spermidine synthase;
EC=2.5.1.16;
AltName: Full=Putrescine aminopropyltransferase;
Short=PAPT;
AltName: Full=SPDSY;
end case
Gene name
speE


FUNCTION Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity).
CATALYTIC ACTIVITY S-adenosylmethioninamine + putrescine = S-methyl-5'-thioadenosine + spermidine.
PATHWAY Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine; step 1/1.
case <OC:Proteobacteria>
SUBUNIT Homodimer and homotetramer (By similarity).
end case
case <OC:Thermotogales>
SUBUNIT Homotetramer (By similarity).
end case
case not <OC:Proteobacteria> and not <OC:Thermotogales>
SUBUNIT Homodimer or homotetramer (By similarity).
end case
SIMILARITY Belongs to the spermidine/spermine synthase family.
case not <FTTag:Act_site>
CAUTION Lacks the conserved Asp active site.
end case


Polyamine biosynthesis
Spermidine biosynthesis
Transferase


GO:0004766; Molecular function: spermidine synthase activity.
GO:0008295; Biological process: spermidine biosynthetic process.


Pfam PF01564; Spermine_synth; 1;
TIGRFAMs TIGR00417; SpeE; 1;
PROSITE PS01330; SPERMIDINE_SYNTHASE_1; 1;
PS51006; SPERMIDINE_SYNTHASE_2; 1;


From: SPEE_ECOLI (P09158)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     140     141       S-adenosylmethioninamine binding (By similarity)     [DN]-[AGV]  
ACT_SITE     158     158       Proton acceptor (By similarity)   Act_site   D  
BINDING (Optional)     33     33       S-adenosylmethioninamine (By similarity)     [QNR]  
BINDING (Optional)     63     63       Putrescine (By similarity)     Y  
BINDING (Optional)     88     88       S-adenosylmethioninamine (By similarity)     [DE]  
BINDING (Optional)     108     108       S-adenosylmethioninamine (By similarity)     [ED]  
BINDING (Optional)     161     161       Putrescine (By similarity)     [DENQ]  
BINDING (Optional)     226     226       Putrescine (By similarity)     Y  


Size range: 261-366 amino acids
Related Rules: None
Templates: P09158 (SPEE_ECOLI); P70998 (SPEE_BACSU); Q9WZC2 (SPEE_THEMA); Q8U4G1 (SPEE_PYRFU); O25503 (SPEE_HELPY): [Recover all]
Fusion: Nter: <Unknown>; Cter: <Unknown>


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