HAMAP

Accession	MF_00205
Dates	1-JUN-2001 (Created) 19-MAY-2011 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00205; [distribution of match scores in UniProtKB];[seed alignment for MF_00205]

Names

UvrA

Identifier

UVRA

Protein name

RecName: Full=UvrABC system protein A; Short=UvrA protein; AltName: Full=Excinuclease ABC subunit A;

Gene name

uvrA

FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity).

SUBUNIT: Forms a heterotetramer with UvrB during the search for lesions (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.

SIMILARITY: Contains 2 ABC transporter domains.

Pfam	PF00005; ABC_tran; 1;
TIGRFAMs	TIGR00630; Uvra; 1;
PROSITE	PS00211; ABC_TRANSPORTER_1; 1; PS50893; ABC_TRANSPORTER_2; 1; trigger=PRU00434;

Cytoplasm, DNA damage, SOS response, Excision nuclease, DNA repair, DNA excision, ATP-binding, Nucleotide-binding, DNA-binding, Repeat.

Metal-binding, Zinc, Zinc-finger.

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0009381; Molecular function: excinuclease ABC activity.

GO:0008270; Molecular function: zinc ion binding.

GO:0006281; Biological process: DNA repair.
GO:0006289; Biological process: nucleotide-excision repair.
GO:0009432; Biological process: SOS response.
GO:0005737; Cellular component: cytoplasm.

From: UVRA_ECOLI (P0A698)
Key		From		To		Description		Condition		FTGroup
NP_BIND		31		38		ATP (Potential)		G-x-S-G-S-G-K-S
ZN_FING		253		280		C4-type		C-x(2,3)-[CH]-x(20)-C-x(2)-C
NP_BIND		640		647		ATP (Potential)		G-x-S-G-[GS]-G-K-S
ZN_FING		740		766		C4-type		C-x(2)-C-x(19)-C-x(2)-C

Size range:	916-1016 amino acids
Related UniRules:	None
Template:	P0A698 (UVRA_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Internal duplication in CHLPN and CHLTR. These sequences were not used in the alignment as both half of these sequences are divergent compared to other uvrA