HAMAP

Accession	MF_00207
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 19)

Name

PPase_C

Scope

Bacteria Archaea

Triggered by

HAMAP; MF_00207 (Get profile general information and statistics)

Identifier

PPAC

Protein name

RecName: Full=Probable manganese-dependent inorganic pyrophosphatase; EC=3.6.1.1; AltName: Full=Pyrophosphate phospho-hydrolase; Short=PPase;

Gene name

ppaC

CATALYTIC ACTIVITY

Diphosphate + H(2)O = 2 phosphate.

COFACTOR

Binds 2 manganese ions per subunit (By similarity).

SUBCELLULAR LOCATION	Cytoplasm (By similarity).
SIMILARITY	Belongs to the PPase class C family.

Cytoplasm
Hydrolase

Manganese
Metal-binding

GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF01368; DHH; 1;
	PF02833; DHHA2; 1;

From: PPAC_BACSU (P37487)
Key		From		To		Description		Tag		Condition		FTGroup
METAL		9		9		Manganese 1 (By similarity)				H		1
METAL		13		13		Manganese 1 (By similarity)				D		1
METAL		15		15		Manganese 2 (By similarity)				D		1
METAL		75		75		Manganese 1 (By similarity)				D		1
METAL		75		75		Manganese 2 (By similarity)				D		1
METAL		97		97		Manganese 2 (By similarity)				H		1
METAL		149		149		Manganese 2 (By similarity)				D		1

Size range:	307-336 amino acids
Related Rules:	None
Templates:	P37487 (PPAC_BACSU); Q58025 (PPAC_METJA): [Recover all]
Fusion:	None
Comments:	The sequence of ppaC in THEMA is interrupted by a 130-residue insert that contains 2 CBS domains.

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