HAMAP rule MF_00209
General rule information
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| Accession | MF_00209 |
| Dates | 1-JUN-2001 (Created)
13-JAN-2023 (Last updated, Version 36) |
| Name | Inorganic_PPase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC); P80562 (IPYR_NOSS1); P9WI55 (IPYR_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00209 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | IPYR |
| Protein name | RecName: Full=Inorganic pyrophosphatase; EC=3.6.1.1; AltName: Full=Pyrophosphate phospho-hydrolase; Short=PPase; |
| Gene name | Name=ppa; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. |
| CATALYTIC ACTIVITY | Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=3.6.1.1; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Homohexamer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the PPase family. |
Keywords
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Gene Ontology
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| GO:0004427; Molecular function:inorganic diphosphate phosphatase activity |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: IPYR_MYCTU (P9WI55) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Actinomycetota> | ||||||||||||
| ACT_SITE | 89 | 89 | /note="Proton acceptor" | D | ||||||||
| BINDING | 8 | 8 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
E | ||||||||
| BINDING | 52 | 52 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 57 | 57 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 57 | 57 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 84 | 84 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3" |
D | ||||||||
| BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3" |
D | ||||||||
| end case | ||||||||||||
| BINDING | 16 | 16 | /ligand="substrate" | K | ||||||||
| BINDING | 30 | 30 | /ligand="substrate" | R | ||||||||
| BINDING | 42 | 42 | /ligand="substrate" | Y | ||||||||
| BINDING | 126 | 126 | /ligand="substrate" | Y | ||||||||
| From: IPYR_ECOLI (P0A7A9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case not <OC:Actinomycetota> | ||||||||||||
| BINDING | 66 | 66 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 71 | 71 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 71 | 71 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 103 | 103 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 158-215 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |