Annotation rule MF_00209
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General rule information [?]

Accession MF_00209
Dates 1-JUN-2001 (Created)
10-OCT-2014 (Last updated, Version 29)
Name Inorganic_PPase
Scope Bacteria
Archaea
Templates P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IPYR
Protein name
RecName: Full=Inorganic pyrophosphatase;
EC=3.6.1.1;
AltName: Full=Pyrophosphate phospho-hydrolase;
Short=PPase;
Gene name
ppa

Comments [?]

Catalytic activity Diphosphate + H(2)O = 2 phosphate.
Cofactor Mg(2+)
Note: Binds 4 Mg(2+) ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg(2+) ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg(2+) ions form complexes with substrate and product.
Subcellular location Cytoplasm.
Similarity Belongs to the PPase family.

Keywords [?]


Gene Ontology [?]

GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00719; Pyrophosphatase; 1;
PROSITE PS00387; PPASE; 1;

Features [?]

From: IPYR_ECOLI (P0A7A9)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     66     66       Magnesium 1     D  
METAL     71     71       Magnesium 1     D  
METAL     71     71       Magnesium 2     D  
METAL     103     103       Magnesium 1     D  

Additional information [?]

Size range 158-215 amino acids
Related rules None
Fusion None