HAMAP annotation rule MF_00209
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Accession MF_00209
Dates 1-JUN-2001 (Created)
9-DEC-2011 (Last updated, Version 27)
Name Inorganic_PPase
Scope Bacteria
Archaea
Triggered by



Identifier
IPYR
Protein name
RecName: Full=Inorganic pyrophosphatase;
EC=3.6.1.1;
AltName: Full=Pyrophosphate phospho-hydrolase;
Short=PPase;
Gene name
ppa


CATALYTIC ACTIVITY Diphosphate + H(2)O = 2 phosphate.
COFACTOR Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product (By similarity).
SUBCELLULAR LOCATION Cytoplasm (By similarity).
SIMILARITY Belongs to the PPase family.


Cytoplasm
Hydrolase
Magnesium
Metal-binding


GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.


Pfam PF00719; Pyrophosphatase; 1;
PROSITE PS00387; PPASE; 1;


From: IPYR_ECOLI (P0A7A9)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     66     66       Magnesium 1 (By similarity)     D  
METAL     71     71       Magnesium 1 (By similarity)     D  
METAL     71     71       Magnesium 2 (By similarity)     D  
METAL     103     103       Magnesium 1 (By similarity)     D  


Size range: 158-215 amino acids
Related Rules: None
Templates: P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC): [Recover all]
Fusion: None


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