Annotation rule MF_00211
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General rule information [?]

Accession MF_00211
Dates 1-JUN-2001 (Created)
25-FEB-2014 (Last updated, Version 30)
Name TrpD
Scope Bacteria
Archaea
Templates P50384 (TRPD_SULSO); P9WFX5 (TRPD_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRPD
Protein name
RecName: Full=Anthranilate phosphoribosyltransferase;
EC=2.4.2.18;
Gene name
trpD

Comments [?]

Function Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) (By similarity).
Catalytic activity N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
Cofactor Binds 2 magnesium ions per monomer (By similarity).
Pathway Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate; step 2/5.
Subunit Homodimer (By similarity).
Similarity Belongs to the anthranilate phosphoribosyltransferase family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0004048; Molecular function: anthranilate phosphoribosyltransferase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.

Cross-references [?]

Pfam PF00591; Glycos_transf_3; 1;
PF02885; Glycos_trans_3N; 1;
TIGRFAMs TIGR01245; TrpD; 1;

Features [?]

From: TRPD_MYCTU (P9WFX5)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     110     111       Phosphoribosylpyrophosphate binding (By similarity)     G-[DSN]  
REGION (Optional)     117     120       Phosphoribosylpyrophosphate binding (By similarity)     N-x-[ST]-[TS]  
REGION (Optional)     135     143       Phosphoribosylpyrophosphate binding (By similarity)     K-x(2)-[NGAS]-x(3)-[TSV]-[SG]  
METAL     119     119       Magnesium 1 (By similarity)     [ST]  
METAL     251     251       Magnesium 2 (By similarity)     D  
METAL     252     252       Magnesium 1 (By similarity)     E  
METAL     252     252       Magnesium 2 (By similarity)     E  
BINDING     107     107       Phosphoribosylpyrophosphate; via amide nitrogen (By similarity)     G  
BINDING     115     115       Phosphoribosylpyrophosphate (By similarity)     [TS]  
BINDING     147     147       Phosphoribosylpyrophosphate; via amide nitrogen (By similarity)     [GA]  
From: TRPD_SULSO (P50384)
BINDING     79     79       Anthranilate 1; via carbonyl oxygen (By similarity)     G  
BINDING     109     109       Anthranilate 1 (By similarity)     N  
BINDING     118     118       Phosphoribosylpyrophosphate; via amide nitrogen (By similarity)     [ST]  
BINDING     164     164       Anthranilate 2 (By similarity)     R  

Additional information [?]

Size range 320-370 amino acids
Related rules None
Fusion Nter: MF_00134 (trpC), <glutamine amidotransferase type-1 domain>; Cter: None
Comments There are divergent trpD-like proteins in AQUAE (O66585) and ECOLI (P30177)