HAMAP rule MF_00211
General rule information
[?]
| Accession | MF_00211 |
| Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 40) |
| Name | TrpD |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P50384 (TRPD_SACS2); P9WFX5 (TRPD_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00211 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | TRPD |
| Protein name | RecName: Full=Anthranilate phosphoribosyltransferase; EC=2.4.2.18; |
| Gene name | Name=trpD; |
Comments
[?]
| FUNCTION | Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). |
| CATALYTIC ACTIVITY | Reaction=diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5- phospho-alpha-D-ribose 1-diphosphate + anthranilate; Xref=Rhea:RHEA:11768, ChEBI:CHEBI:16567, ChEBI:CHEBI:18277, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017; EC=2.4.2.18; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per monomer.; |
| PATHWAY | Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 2/5. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the anthranilate phosphoribosyltransferase family. |
Keywords
[?]
| Amino-acid biosynthesis |
| Aromatic amino acid biosynthesis |
| Tryptophan biosynthesis |
| Transferase |
| Glycosyltransferase |
| Magnesium |
| Metal-binding |
Gene Ontology
[?]
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0004048; Molecular function:anthranilate phosphoribosyltransferase activity |
| GO:0000162; Biological process:tryptophan biosynthetic process |
Cross-references
[?]
Features
[?]
| From: TRPD_MYCTU (P9WFX5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 110 | 111 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
G-[DSN] | ||||||||
| BINDING | 117 | 120 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
N-x-[ST]-[TS] | ||||||||
| BINDING | 135 | 143 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
K-x(2)-[NGAS]-x(3)-[TSV]-[SG] | ||||||||
| BINDING | 119 | 119 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
[ST] | ||||||||
| BINDING | 251 | 251 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 252 | 252 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
E | ||||||||
| BINDING | 252 | 252 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
E | ||||||||
| BINDING | 107 | 107 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
G | ||||||||
| BINDING | 115 | 115 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
[TS] | ||||||||
| BINDING | 147 | 147 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
[GA] | ||||||||
| From: TRPD_SACS2 (P50384) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 79 | 79 | /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1" |
G | ||||||||
| BINDING | 109 | 109 | /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="1" |
N | ||||||||
| BINDING | 118 | 118 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
[ST] | ||||||||
| BINDING | 164 | 164 | /ligand="anthranilate" /ligand_id="ChEBI:CHEBI:16567" /ligand_label="2" |
R | ||||||||
Additional information
[?]
| Size range | 320-370 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_00134 (trpC); <glutamine amidotransferase type-1 domain> Cter: None |
| Comments | There are divergent trpD-like proteins in AQUAE (O66585) and ECOLI (P30177) |