HAMAP rule MF_00214
General rule information
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| Accession | MF_00214 |
| Dates | 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 42) |
| Name | AroD |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P05194 (AROD_ECOLI); P24670 (AROD_SALTI); P58687 (AROD_SALTY); Q186A6 (AROD_CLOD6); Q6GII7 (AROD_STAAR); O30011 (AROD_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00214 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AROD |
| Protein name | RecName: Full=3-dehydroquinate dehydratase; Short=3-dehydroquinase; EC=4.2.1.10; AltName: Full=Type I dehydroquinase; Short=DHQ1; AltName: Full=Type I DHQase; |
| Gene name | Name=aroD; |
Comments
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| FUNCTION | Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. |
| CATALYTIC ACTIVITY | Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xref=Rhea:RHEA:21096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630, ChEBI:CHEBI:32364; EC=4.2.1.10; |
| PATHWAY | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the type-I 3-dehydroquinase family. |
Keywords
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Gene Ontology
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| GO:0003855; Molecular function:3-dehydroquinate dehydratase activity |
| GO:0009423; Biological process:chorismate biosynthetic process |
Cross-references
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Features
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| From: AROD_SALTY (P58687) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 46 | 48 | /ligand="3-dehydroquinate" /ligand_id="ChEBI:CHEBI:32364" |
E-x-R | ||||||||
| ACT_SITE | 143 | 143 | /note="Proton donor/acceptor" | H | ||||||||
| ACT_SITE | 170 | 170 | /note="Schiff-base intermediate with substrate" | K | ||||||||
| BINDING | 21 | 21 | /ligand="3-dehydroquinate" /ligand_id="ChEBI:CHEBI:32364" |
S | ||||||||
| BINDING | 82 | 82 | /ligand="3-dehydroquinate" /ligand_id="ChEBI:CHEBI:32364" |
R | ||||||||
| BINDING | 213 | 213 | /ligand="3-dehydroquinate" /ligand_id="ChEBI:CHEBI:32364" |
R | ||||||||
| BINDING | 232 | 232 | /ligand="3-dehydroquinate" /ligand_id="ChEBI:CHEBI:32364" |
[ST] | ||||||||
| BINDING | 236 | 236 | /ligand="3-dehydroquinate" /ligand_id="ChEBI:CHEBI:32364" |
Q | ||||||||
Additional information
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| Size range | 196-272 amino acids |
| Related rules |
MF_03143 |
| Fusion | Nter: None Cter: MF_00222 (aroE); <Chorismate mutase> |
| Comments | There are two type of DHQases, B.subtilis seems to have both. AroD can be confused with of DHQases involved in catabolism (quiB) or in other pathways (example ebsD). |