Annotation rule MF_00219
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General rule information [?]

Accession MF_00219
Dates 1-JUN-2001 (Created)
19-MAY-2011 (Last updated, Version 30)
Name PyrC_type1
Scope Bacteria

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PYRC
Protein name
RecName: Full=Dihydroorotase;
Short=DHOase;
EC=3.5.2.3;
Gene name
pyrC

Comments [?]

Catalytic activity (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.
Cofactor Binds 2 zinc ions per subunit (By similarity).
Pathway Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate; step 3/3.
Subunit Homodimer (By similarity).
Similarity Belongs to the DHOase family. Type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004151; Molecular function: dihydroorotase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
PIRSF PIRSF001237; DHOdimr; 1;
TIGRFAMs TIGR00856; PyrC_dimer; 1;
PROSITE PS00482; DIHYDROOROTASE_1; 1;
PS00483; DIHYDROOROTASE_2; 1;

Features [?]

From: PYRC_ECOLI (P05020)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     17     17       Zinc 1 (By similarity)     H  
METAL     19     19       Zinc 1 (By similarity)     H  
METAL     103     103       Zinc 1; via carbamate group (By similarity)     K  
METAL     103     103       Zinc 2; via carbamate group (By similarity)     K  
METAL     140     140       Zinc 2 (By similarity)     H  
METAL     178     178       Zinc 2 (By similarity)     H  
METAL     251     251       Zinc 1 (By similarity)     D  
MOD_RES     103     103       N6-carboxylysine (By similarity)     K  

Additional information [?]

Size range 339-350 amino acids
Related rules MF_00220 (PYRC)
Template P05020 (PYRC_ECOLI)
Fusion None