Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_00223
Send feedback

General rule information [?]

Accession MF_00223
Dates 1-JUN-2001 (Created)
26-SEP-2014 (Last updated, Version 36)
Name FolE
Scope Bacteria
Templates P0A6T5 (GCH1_ECOLI); P19465 (GCH1_BACSU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=GTP cyclohydrolase 1;
AltName: Full=GTP cyclohydrolase I;
Gene name

Comments [?]

Catalytic activity GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
Pathway Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Subunit Homopolymer.
Similarity Belongs to the GTP cyclohydrolase I family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0003934; Molecular function: GTP cyclohydrolase I activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0006730; Biological process: one-carbon metabolic process.
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.

Cross-references [?]

Pfam PF01227; GTP_cyclohydroI; 1;
TIGRFAMs TIGR00063; FolE; 1;
PS00860; GTP_CYCLOHYDROL_1_2; 1;

Features [?]

From: GCH1_ECOLI (P0A6T5)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     111     111       Zinc     C   1
METAL     114     114       Zinc     H   1
METAL     182     182       Zinc     C   1

Additional information [?]

Size range 180-235 amino acids
Related rules None
Fusion Nter: MF_xxxxx (folK); Cter: None
Comments The GTP cyclohydrolases of this family share the same function as the bacterial GTP cyclohydrolases of the MF_01527 family (GTP cyclohydrolases folE2), without having any sequence homology.