HAMAP

Accession	MF_00223
Dates	1-JUN-2001 (Created) 19-MAY-2011 (Last updated, Version 35)

Data class

Protein

Predictors

HAMAP; MF_00223; [distribution of match scores in UniProtKB];[seed alignment for MF_00223]

Names

FolE

Identifier

GCH1

Protein name

RecName: Full=GTP cyclohydrolase 1; EC=3.5.4.16; AltName: Full=GTP cyclohydrolase I; Short=GTP-CH-I;

Gene name

folE

CATALYTIC ACTIVITY: GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.

SUBUNIT: Homopolymer (By similarity).

SIMILARITY: Belongs to the GTP cyclohydrolase I family.

Pfam	PF01227; GTP_cyclohydroI; 1;
TIGRFAMs	TIGR00063; FolE; 1;
PROSITE	PS00859; GTP_CYCLOHYDROL_1_1; 1; PS00860; GTP_CYCLOHYDROL_1_2; 1;

GTP-binding, Nucleotide-binding, One-carbon metabolism, Hydrolase.

Metal-binding, Zinc.

GO:0003934; Molecular function: GTP cyclohydrolase I activity.

GO:0008270; Molecular function: zinc ion binding.

GO:0006730; Biological process: one-carbon metabolic process.
GO:0046654; Biological process: tetrahydrofolate biosynthetic process.

From: GCH1_ECOLI (P0A6T5)
Key		From		To		Description		Condition		FTGroup
METAL		111		111		Zinc (By similarity)		C		1
METAL		114		114		Zinc (By similarity)		H		1
METAL		182		182		Zinc (By similarity)		C		1

Size range:	180-235 amino acids
Related UniRules:	None
Template:	P0A6T5 (GCH1_ECOLI); P19465 (GCH1_BACSU): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: MF_xxxxx (folK); Cter: None
Duplicate:	in NOSS1, PSEAE, PSEPK, PSESM
Plasmid encoded:	None
Comments:	The GTP cyclohydrolases of this family share the same function as the bacterial GTP cyclohydrolases of the MF_01527 family (GTP cyclohydrolases folE2), without having any sequence homology.