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HAMAP rule MF_00223
General rule information
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| Accession | MF_00223 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41) |
| Name | FolE |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A6T5 (GCH1_ECOLI); P19465 (GCH1_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00223 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GCH1 |
| Protein name | RecName: Full=GTP cyclohydrolase 1; EC=3.5.4.16; AltName: Full=GTP cyclohydrolase I; Short=GTP-CH-I; |
| Gene name | Name=folE; |
Comments
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| CATALYTIC ACTIVITY | Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16; |
| PATHWAY | Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. |
| SUBUNIT | Homopolymer. |
| SIMILARITY | Belongs to the GTP cyclohydrolase I family. |
Keywords
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| GTP-binding | |
| Nucleotide-binding | |
| One-carbon metabolism | |
| Hydrolase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0003934; Molecular function:GTP cyclohydrolase I activity | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0006730; Biological process:one-carbon metabolic process | |
| GO:0046654; Biological process:tetrahydrofolate biosynthetic process | |
Cross-references
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| Pfam | PF01227; GTP_cyclohydroI; 1; |
| NCBIfam | TIGR00063; FolE; 1; |
| PROSITE | PS00859; GTP_CYCLOHYDROL_1_1; 1; |
| PROSITE | PS00860; GTP_CYCLOHYDROL_1_2; 1; |
Features
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| From: GCH1_ECOLI (P0A6T5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 111 | 111 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 114 | 114 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 182 | 182 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 180-235 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_xxxxx (folK) Cter: None |
| Comments | The GTP cyclohydrolases of this family share the same function as the bacterial GTP cyclohydrolases of the MF_01527 family (GTP cyclohydrolases folE2), without having any sequence homology. |