HAMAP rule MF_00228
General rule information
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| Accession | MF_00228 |
| Dates | 1-JUN-2001 (Created)
1-MAR-2024 (Last updated, Version 45) |
| Name | Thz_kinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P39593 (THIM_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00228 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | THIM |
| Protein name | RecName: Full=Hydroxyethylthiazole kinase; EC=2.7.1.50; AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase; Short=TH kinase; Short=Thz kinase; |
| Gene name | Name=thiM; |
Comments
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| FUNCTION | Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ). |
| CATALYTIC ACTIVITY | Reaction=5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2- phosphooxyethyl)-thiazole + ADP + H(+); Xref=Rhea:RHEA:24212, ChEBI:CHEBI:15378, ChEBI:CHEBI:17957, ChEBI:CHEBI:30616, ChEBI:CHEBI:58296, ChEBI:CHEBI:456216; EC=2.7.1.50; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4- methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4- methylthiazole: step 1/1. |
| SIMILARITY | Belongs to the Thz kinase family. |
Keywords
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Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0005524; Molecular function:ATP binding |
| GO:0004417; Molecular function:hydroxyethylthiazole kinase activity |
| GO:0009229; Biological process:thiamine diphosphate biosynthetic process |
Cross-references
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Features
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| From: THIM_BACSU (P39593) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 45 | 45 | /ligand="substrate" | M | ||||||||
| BINDING | 121 | 121 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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| BINDING | 168 | 168 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ST] | ||||||||
| BINDING | 195 | 195 | /ligand="substrate" | [GA] | ||||||||
Additional information
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| Size range | 220-320 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_00097 (thiE) |
| Comments | AGRFC has internal deletion; not shown in alignment or used in size range. Fusion with thiE in SYMTH. |