HAMAP

Accession	MF_00229
Dates	1-JUN-2001 (Created) 19-MAY-2011 (Last updated, Version 28)

Data class

Protein

Predictors

HAMAP; MF_00229; [distribution of match scores in UniProtKB];[seed alignment for MF_00229]

Names

His_ammonia-lyase

Identifier

HUTH

Protein name

RecName: Full=Histidine ammonia-lyase; Short=Histidase; EC=4.3.1.3;

Protein name

RecName: Full=Probable histidine ammonia-lyase; Short=Histidase; EC=4.3.1.3;

Gene name

hutH

CATALYTIC ACTIVITY: L-histidine = urocanate + NH(3).

PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.

SUBCELLULAR LOCATION: Cytoplasm (Potential).

PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly (By similarity).

PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly (By similarity).

PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly (By similarity).

SIMILARITY: Belongs to the PAL/histidase family.

Pfam	PF00221; PAL; 1;
TIGRFAMs	TIGR01225; HutH; 1;
PROSITE	PS00488; PAL_HISTIDASE; 1;

Cytoplasm, Lyase, Histidine metabolism.

GO:0004397; Molecular function: histidine ammonia-lyase activity.
GO:0006548; Biological process: histidine catabolic process.
GO:0005737; Cellular component: cytoplasm.

From: HUTH_PSEPU (P21310)
Key		From		To		Description		Condition		FTGroup
MOD_RES		144		144		2,3-didehydroalanine (Ser) (By similarity)		S
CROSSLNK		143		145		5-imidazolinone (Ala-Gly) (By similarity)		[CSA]-S-G

Size range:	495-525 amino acids
Related UniRules:	None
Template:	P21310 (HUTH_PSEPU)
Scope:	Bacteria Archaea
Fusion:	Nter: MF_00372 (hutI); Cter: None
Duplicate:	in FUSNN
Plasmid encoded:	in AGRRH, RHIME