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HAMAP rule MF_00253

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General rule information [?]

Accession MF_00253
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 31)
Name Gly_tRNA_synth
Scope(s) Bacteria
Archaea
Template(s) P56206 (SYG_THET8); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00253_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_00253_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SYG
Protein name RecName: Full=Glycine--tRNA ligase;
                 EC=6.1.1.14;
AltName: Full=Glycyl-tRNA synthetase;
                 Short=GlyRS;
case <OC:Bacteria>
Gene name Name=glyQS;
end case
case <OC:Archaea>
Gene name Name=glyS;
end case

Comments [?]

FUNCTIONCatalyzes the attachment of glycine to tRNA(Gly).
CATALYTIC ACTIVITY Reaction=ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl- tRNA(Gly); Xref=Rhea:RHEA:16013, Rhea:RHEA-COMP:9664, Rhea:RHEA- COMP:9683, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57305, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522, ChEBI:CHEBI:456215; EC=6.1.1.14;
case <OC:Bacteria>
SUBUNITHomodimer.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class-II aminoacyl-tRNA synthetase family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004820; Molecular function:glycine-tRNA ligase activity
GO:0006426; Biological process:glycyl-tRNA aminoacylation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00587; tRNA-synt_2b; 1;
PRINTS PR01043; TRNASYNTHGLY; 1;
NCBIfam TIGR00389; GlyS_dimeric; 1;
PROSITE PS50862; AA_TRNA_LIGASE_II; 1;

Features [?]

From: SYG_THET8 (P56206)
Key From To Description Tag Condition FTGroup
case <OC:Bacteria>
BINDING 221 223 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
R-N-E
BINDING 231 236 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
[FILV]-R-x(3)-[FL]
BINDING 305 306 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
E-[CILV]
BINDING 364 367 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-x(2)-R
BINDING 236 240 /ligand="substrate" [FL]-x-Q-x-E
BINDING 360 364 /ligand="substrate" E-x(3)-G
BINDING 99 99 /ligand="substrate" [KR]
BINDING 189 189 /ligand="substrate" E
end case
From: SYG_METJA (Q57681)
Key From To Description Tag Condition FTGroup
case <OC:Archaea>
BINDING 196 198 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
R-N-E
BINDING 206 211 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
[FILV]-R-x(3)-F
BINDING 328 329 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
E-[CILV]
BINDING 451 454 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-x(2)-R
BINDING 211 215 /ligand="substrate" F-x(3)-E
BINDING 447 451 /ligand="substrate" E-x(3)-G
BINDING 98 98 /ligand="substrate" R
BINDING 164 164 /ligand="substrate" E
end case

Additional information [?]

Size range 565-583 amino acids
Related rules None
Fusion Nter: None Cter: None



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