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HAMAP annotation rule: MF_00260
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General rule information

Accession MF_00260
Dates 1-JUN-2001 (Created)
19-SEP-2011 (Last updated, Version 34)
Data class Protein
Predictors HAMAP; MF_00260; [distribution of match scores in UniProtKB];[seed alignment for MF_00260]
Names Porphobil_deam


Propagated annotation

Identifier, protein and gene names
Identifier HEM3

case <OC:Bacteria>
Protein name
RecName: Full=Porphobilinogen deaminase;
Short=PBG;
EC=2.5.1.61;
AltName: Full=Hydroxymethylbilane synthase;
Short=HMBS;
AltName: Full=Pre-uroporphyrinogen synthase;
end case


case <OC:Archaea>
Protein name
RecName: Full=Probable porphobilinogen deaminase;
Short=PBG;
EC=2.5.1.61;
AltName: Full=Hydroxymethylbilane synthase;
Short=HMBS;
AltName: Full=Pre-uroporphyrinogen synthase;
end case

Gene name hemC
Comments
FUNCTION: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity).
CATALYTIC ACTIVITY: 4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3).
COFACTOR: Binds 1 dipyrromethane group covalently (By similarity).

case not <Property:PHOTOSYN>
PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
end case


case <Property:PHOTOSYN>
PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis.
end case


case <OC:Bacteria>
SUBUNIT: Monomer (By similarity).
end case

MISCELLANEOUS: The porphobilinogen subunits are added to the dipyrromethane group (By similarity).
SIMILARITY: Belongs to the HMBS family.
Cross-references
Pfam PF01379; Porphobil_deam; 1;
PRINTS PR00151; PORPHBDMNASE; 1;
TIGRFAMs TIGR00212; HemC; 1;
PROSITE PS00533; PORPHOBILINOGEN_DEAM; 1;
Keywords
Porphyrin biosynthesis.

case <Property:PHOTOSYN>
Chlorophyll biosynthesis.
end case

Transferase.
Gene Ontology
GO:0004418; Molecular function: hydroxymethylbilane synthase activity.

case <Property:PHOTOSYN>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case

GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
Features
From: HEM3_ECOLI (P06983)
Key     From     To       Description   Condition   FTGroup
MOD_RES     242     242       S-(dipyrrolylmethanemethyl)cysteine (By similarity)   C  


Additional information

Size range: 282-395 amino acids
Related UniRules: None
Template: P06983 (HEM3_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in STRAW, STRCO
Plasmid encoded: None
Comments: Chlamydial hemC are divergent and lack the cofactor binding site, they are shorter and they have not been included in the alignment. HALSA and PAEMA have atypical inserts. RPE1 type insert in RICCN.

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UniProtKB rule member sequences